AI Article Synopsis
- * A new fluorescent probe, DNO-HC, was developed to quickly detect glutathione (GSH) in gut bacteria, offering high selectivity and sensitivity.
- * This probe not only helps assess metabolic levels in bacteria but also determines their antibiotic resistance, suggesting a new approach to treat bacterial infections.
Article Abstract
The human gut microbiota plays an integral role in the management of human health. Effective detection of gut-derived bacteria and their metabolites, as well as assessing antibiotic susceptibility, are crucial for the treatment of intestinal bacteria-related diseases. Herein, we designed and developed a dual-site (nitrophenyl sulfide group and aldehyde group) fluorescent probe DNO-HC, which could rapidly (∼1 min) respond to glutathione (GSH) with low background fluorescence, high selectivity, and low detection limits (45 nM). Moreover, the probe can be used to evaluate the metabolic levels (GSH) in different gut-derived bacteria and discriminate their Gram status. Remarkably, the assessment of antimicrobial susceptibility to a variety of antibiotics has been successfully accomplished utilizing this probe. It offers a promising strategy for the treatment of diseases associated with bacterial infections.
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| http://dx.doi.org/10.1016/j.saa.2024.125408 | DOI Listing |
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