Synergistic approach of ertapenem and flucloxacillin or cefazolin for addressing persistent methicillin susceptible Staphylococcus aureus bacteremia.

In the present study, we determine the synergistic activity of ertapenem with cefazolin and flucloxacillin against type A beta-lactamase producing Methicillin susceptible Staphylococcus aureus isolate. In the time kill assay, at standard inoculum, ertapenem with cefazolin showed >1 log kill and ertapenem with flucloxacillin demonstrated >2 log kill. When tested at high inoculum, both combinations achieved >1 log kill at 1x MIC.