Time is brain: detection of nonconvulsive seizures and status epilepticus during acute stroke evaluation using point-of-care electroencephalography.

J Stroke Cerebrovasc Dis

Department of Neurology, Providence Mission Medical Center, Mission Viejo, CA, USA; Department of Neurology, Keck School of Medicine at USC, Los Angeles, CA, USA. Electronic address:

Published: November 2024

AI Article Synopsis

  • - The study investigates the use of a point-of-care EEG device to help differentiate between seizures and actual strokes during acute stroke evaluations, where timing is critical.
  • - Conducted retrospectively at a teaching hospital, the study involved 70 patients monitored with the Rapid Response EEG system and revealed that 38 were diagnosed with strokes while 32 were not.
  • - The findings showed that the point-of-care EEG detected seizures in 15.8% of stroke patients and 34.4% of stroke-mimic patients, highlighting its effectiveness in identifying nonconvulsive seizures in emergency situations.

Article Abstract

Objectives: Seizures are both a common mimic and a potential complication of acute stroke. Although EEG can be helpful to evaluate this differential diagnosis, conventional EEG infrastructure is resource-intensive and unable to provide timely monitoring to match the emergent context of a stroke code. We aimed to evaluate the real-world use and utility of a point-of-care EEG device as an adjunct to acute stroke evaluation.

Materials And Methods: We performed a retrospective observational cohort study at a tertiary care community teaching hospital by identifying patients who underwent point-of-care EEG monitoring using Rapid Response EEG system (Ceribell Inc., Sunnyvale, CA) during stroke code evaluation of acute neurological deficits during the study period from January 1, 2020 to December 31, 2020. We assessed the frequency of seizures and highly epileptiform patterns among patients with either confirmed strokes or stroke mimics.

Results: Point-of-care EEG monitoring was used in the wake of a stroke code in 70 patients. Of these, neuroimaging and clinical information resulted in a diagnosis of stroke in 38 patients (28 ischemic, 6 hemorrhagic, 4 transient ischemic attack; median NIHSS score of 6.5 [IQR 2.0-12.0]) and absence of any stroke in 32 patients. Point-of-care EEG detected seizures and highly epileptiform patterns in 6 (15.8 %) stroke patients and 11 (34.4 %) stroke-mimic patients, including 2 patients with persistent expressive aphasia due to repeated focal seizures.

Conclusions: Point-of-care EEG has utility for detecting nonconvulsive seizures in patients undergoing acute stroke evaluations.

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http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2024.108116DOI Listing

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Time is brain: detection of nonconvulsive seizures and status epilepticus during acute stroke evaluation using point-of-care electroencephalography.

J Stroke Cerebrovasc Dis

November 2024

Department of Neurology, Providence Mission Medical Center, Mission Viejo, CA, USA; Department of Neurology, Keck School of Medicine at USC, Los Angeles, CA, USA. Electronic address:

Article Synopsis
  • - The study investigates the use of a point-of-care EEG device to help differentiate between seizures and actual strokes during acute stroke evaluations, where timing is critical.
  • - Conducted retrospectively at a teaching hospital, the study involved 70 patients monitored with the Rapid Response EEG system and revealed that 38 were diagnosed with strokes while 32 were not.
  • - The findings showed that the point-of-care EEG detected seizures in 15.8% of stroke patients and 34.4% of stroke-mimic patients, highlighting its effectiveness in identifying nonconvulsive seizures in emergency situations.
View Article and Find Full Text PDF

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