AI Article Synopsis
- Di-2-ethylhexyl phthalate (DEHP) is a common plasticizer that can enter the body and accumulate in key organs like the lungs and kidneys, potentially harming their function.
- Recent studies highlight the increasing concern over DEHP's nephrotoxicity, indicating that exposure may lead to kidney damage and worsen existing kidney diseases.
- The review explores the molecular mechanisms behind DEHP-related kidney injury, including various damaging pathways, and evaluates potential protective effects of compounds like lycopene, green tea polyphenols, and quercetin.
Article Abstract
Di-2-ethylhexyl phthalate (DEHP), a widely applied plasticizer in various products, can be absorbed into the human body through several channels and accumulate in the lungs, liver, testes, and kidneys, potentially impairing the function of these organs. Recently, the nephrotoxicity of DEHP has received heightened attention. Numerous epidemiologic findings have demonstrated that DEHP exposure may contribute to renal damage, leading to structural and functional abnormalities and exacerbating the progression of kidney disease. Recent research has discovered the mechanisms behind DEHP-induced nephrotoxicity may involve a variety of pathways, including apoptosis, autophagy, ferroptosis, oxidative stress, inflammation, DNA damage, and lipid metabolism disorders. This review discusses the impact of DEHP on kidney function and delves into the molecular mechanisms of nephrotoxicity mediated by DEHP in recent years. In addition, the review examines evidence for the antioxidant and anti-inflammatory capacities of lycopene, green tea polyphenols, and quercetin in ameliorating DEHP-induced renal injury is reviewed, providing a basis for further research.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cbi.2024.111310 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Scrolled Poly(L-lactic acid) Single Crystals via Chain End-Induced Symmetry-Breaking.
Angew Chem Int Ed Engl
January 2025
The University of Tennessee Knoxville, Chemistry, UNITED STATES OF AMERICA.
Single crystals that do not obey translational symmetry have been reported in various material systems. In polymers, twisted crystals are typically formed in banded spherulites, while a class of non-flat polymer single crystals (PSCs) has been observed. Herein, we report the formation of scrolled single crystals of biodegradable polymer poly(L-lactic acid) (PLLA).
View Article and Find Full Text PDFCanonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer: distinct and concerted control.
Front Med
January 2025
Zhejiang University-University of Edinburgh Institute, School of Medicine, Zhejiang University, Jiaxing, 314400, China.
Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice. While target mutations are well recognized as the basis of genetic resistance to targeted therapy, nontarget mutation resistance (or nongenetic resistance) remains poorly characterized. Despite its complex and unintegrated mechanisms in the literature, nongenetic resistance is considered from our perspective to be a collective response of innate or acquired resistant subpopulations in heterogeneous tumors to therapy.
View Article and Find Full Text PDFOptimized smFISH Pipeline for Studying Nascent Transcription in Mouse Embryonic Tissue Samples.
Methods Mol Biol
January 2025
Stowers Institute for Medical Research, Kansas City, MO, USA.
Understanding the spatial and temporal dynamics of gene expression is crucial for unraveling molecular mechanisms underlying various biological processes. While traditional methods have offered insights into gene expression patterns, they primarily focus on mature mRNA transcripts, lacking real-time visualization of newly synthesized or nascent transcription events. Recent advancements in monitoring nascent transcription in live cells provide valuable insights into transcriptional dynamics.
View Article and Find Full Text PDFConfined Flash Pt/WC inside Carbon Nanotubes for Efficient and Durable Electrocatalysis.
Nano Lett
January 2025
School of Environment, Tsinghua University, Beijing 100084, China.
Exploiting cost-effective hydrogen evolution reaction (HER) catalysts is crucial for sustainable hydrogen production. However, currently reported nanocatalysts usually cannot simultaneously sustain high catalytic activity and long-term durability. Here, we report the efficient synthesis and activity tailoring of a chainmail catalyst, isolated platinum atom anchored tungsten carbide nanocrystals encapsulated inside carbon nanotubes (Pt/WC@CNTs), by confined flash Joule heating technique.
View Article and Find Full Text PDFAggregation-Induced Emission Luminogens Realizing High-Contrast Bioimaging.
ACS Nano
January 2025
Clinical Translational Research Center of Aggregation-Induced Emission, The Second Affiliated Hospital, School of Medicine, School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Shenzhen, Guangdong 518172, China.
A revolutionary transformation in biomedical imaging is unfolding with the advent of aggregation-induced emission luminogens (AIEgens). These cutting-edge molecules not only overcome the limitations of traditional fluorescent probes but also improve the boundaries of high-contrast imaging. Unlike conventional fluorophores suffering from aggregation-caused quenching, AIEgens exhibit enhanced luminescence when aggregated, enabling superior imaging performance.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!