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| http://dx.doi.org/10.1016/j.ymthe.2024.11.005 | DOI Listing |
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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), Indianapolis, IN, USA.
Background: The National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) is continuing to develop a bank of induced pluripotent stem cells (iPSCs) that are available by request to the Alzheimer's disease (AD) research community.
Methods: As part of the pipeline for quality control of received cell lines, DNA was extracted for all lines and was submitted for whole genome sequencing (WGS). Paired-end WGS data was generated using the Illumina NovaSeq 6000 and processed following GATK best practices using the Sentieon pipeline.
Basic Science and Pathogenesis.
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December 2024
Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.
Background: Classical genome-wide association studies (GWAS) of Alzheimer's disease (AD), which successfully identified over 75 risk loci to date, are limited to the content of the imputation panels that typically do not cover all types of genetic variation, e.g., tandem repeats encompassing >55% of human genome.
View Article and Find Full Text PDFIntegrating Particle Motion Tracking into Thermal Gel Electrophoresis for Label-Free Sugar Sensing.
ACS Sens
January 2025
Department of Chemistry, Wayne State University, 5101 Cass Ave, Detroit, Michigan 48202, United States.
Bioanalytical sensors are adept at quantifying target analytes from complex sample matrices with high sensitivity, but their multiplexing capacity is limited. Conversely, analytical separations afford great multiplexing capacity but typically require analyte labeling to increase sensitivity. Here, we report the development of a separation-based sensor to sensitively quantify unlabeled polysaccharides using particle motion tracking within a microfluidic electrophoresis platform.
View Article and Find Full Text PDFProfessor Dr. Shuying Liu (1943.1-2023.11): A Devoted Mass Spectrometrist and Esteemed Mentor.
J Am Soc Mass Spectrom
January 2025
University of California at Santa Barbara, Santa Barbara. California 93106-9510, United States.
A year has gone by, and it is still hard to believe that Dr. Shuying Liu had left us on November 22, 2023. Most her colleagues and friends remember vividly her passionate images captured in the talk she filmed for the Chinese Mass Spectrometry Conference 2020-2023 in June 2023.
View Article and Find Full Text PDFUnified Knowledge-Guided Molecular Graph Encoder with multimodal fusion and multi-task learning.
Neural Netw
December 2024
School of Computer Science, Wuhan University, Luojiashan Road, Wuchang District., Wuhan, 430072, Hubei Province, China; Hubei Key Laboratory of Digital Finance Innovation, Hubei University of Economics, No. 8, Yangqiaohu Avenue, Zanglong Island Development Zone, Jiangxia District, Wuhan, 2007, Hubei Province, China. Electronic address:
The remarkable success of Graph Neural Networks underscores their formidable capacity to assimilate multimodal inputs, markedly enhancing performance across a broad spectrum of domains. In the context of molecular modeling, considerable efforts have been made to enrich molecular representations by integrating data from diverse aspects. Nevertheless, current methodologies frequently compartmentalize geometric and semantic components, resulting in a fragmented approach that impairs the holistic integration of molecular attributes.
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