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Tenecteplase Thrombolysis for Stroke up to 24 Hours After Onset With Perfusion Imaging Selection: The CHABLIS-T II Randomized Clinical Trial.
Stroke
January 2025
Department of Neurology, National Center for Neurological Disorders, National Clinical Research Centre for Aging and Medicine, Huashan Hospital, Fudan University, Shanghai, China (X.C., L.H., Y.L., Yiran Zhang, X.L., S.L., L.Y., Q.D.).
Background: Whether it is effective and safe to extend the time window of intravenous thrombolysis up to 24 hours after the last known well is unknown. We aimed to determine the efficacy and safety of tenecteplase in Chinese patients with acute ischemic stroke due to large/medium vessel occlusion within an extended time window.
Methods: Patients with ischemic stroke presenting 4.
Somatic symptom and related disorders in a tertiary paediatric hospital: Characteristics of ED use prior to admission.
Emerg Med Australas
February 2025
Centre for Adolescent Health, Murdoch Children's Research Institute and Royal Children's Hospital, Melbourne, Victoria, Australia.
Objectives: Somatic symptom and related disorders (SSRDs) are complex disorders that are commonly encountered in tertiary paediatric settings. Despite this, little is known about ED use prior to hospital admission. We aimed to describe the pattern of ED use in a cohort of children and adolescents who were subsequently admitted to hospital with SSRD and to identify factors associated with ED presentations.
View Article and Find Full Text PDFImpact of the XVII Pacific Games on the National Referral Hospital Emergency Department, Solomon Islands.
Emerg Med Australas
February 2025
Department of Critical Care, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia.
Background: The XVII Pacific Games was held in Honiara, Solomon Islands in 2023 and was attended by competitors from 24 Pacific nations. The National Referral Hospital (NRH) is the sole tertiary hospital and largest emergency department (ED) in the Solomon Islands, located in the capital city, Honiara, and was the designated referral hospital for the Pacific Games.
Objective: This report documents the lessons learnt from supporting a large international sporting event within a resource-limited health setting, and may help other EDs prepare for similar planned mass gatherings.
Deep anaesthesia may increase postoperative delirium and consequently subsequent mortality: A secondary analysis of data from the Balanced randomised trial.
Eur J Anaesthesiol
February 2025
From the Department of Epidemiology, Biostatistics and Occupational Health, Faculty of Medicine, McGill University, Montreal, Canada (JY), Department of Anaesthesia and Perioperative Medicine, Auckland City Hospital, Auckland, New Zealand (TGS), Department of Anaesthesia, University of Auckland, Auckland, New Zealand (TGS), Clinic for Anaesthesiology, Intermediate Care, Prehospital Emergency Medicine and Pain Therapy, Department of Acute Medicine, University Hospital of Basel, Basel, Switzerland (LAS, SD-K), and Department of Clinical Research, University of Basel, Basel, Switzerland (LAS, SD-K).
Intra-operative norepinephrine via peripheral venous catheter is safe: A short scientific report.
Eur J Anaesthesiol
February 2025
From the Division of Anaesthesiology, Intensive Care Medicine, Emergency Medicine and Pain Management, Kantonsspital St. Gallen, St. Gallen (RS, MF), Institute of Anaesthesiology, Stadtspital Zürich Waid, Zürich (RS), Emergency Department, Kantonsspital Winterthur, Winterthur (CAR) and Division of Perioperative Intensive Care Medicine, Kantonsspital St. Gallen, St. Gallen, Switzerland (MF).
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