Vector-Borne disease represent a significant global public health issue, with tsutsugamushi disease (TD) being a notable zoonotic disease transmitted through the bites of chigger larvae. TD is associated with a broad spectrum of complications and is characterized by high rates of morbidity and mortality. Diagnostic, therapeutic, and care standards for TD differ across regions worldwide, and there is a dearth of documented care cases. This case report details a critical TD presentation involving infectious shock and multiple organ failure. After nine days of intensive treatment and nursing intervention, which included correction of hypoxemia, anti-infection measures, antispasmodic and asthmatic management, and stabilization of the internal environment, the patient's condition was effectively managed.
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http://dx.doi.org/10.1016/j.diagmicrobio.2024.116603 | DOI Listing |
J Orthop Trauma
January 2025
Department of Orthopaedics, R Adams Cowley Shock Trauma Center, University of Maryland School of Medicine, Baltimore, MD.
Objective: To determine whether bone transport or Masquelet results in higher rates of major unplanned reoperations for the treatment of segmental tibial bone defects ≥4 cm in length.
Methods: Design: Retrospective cohort.
Setting: Level I trauma center.
J Med Virol
January 2025
Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu, China.
Glucose-regulated protein 78 kDa (GRP78), a key marker of endoplasmic reticulum stress (ERS), is upregulated in hepatocellular carcinoma (HCC) tissues, but its role in hepatitis B virus (HBV)-induced tumorigenesis remains unclear. This study aimed to investigate the contribution of GRP78 to HBV-associated tumor development and explore the ERS pathways involved. The results showed that increased GRP78 expression in patients with HBV-related HCC was associated with a poor prognosis within the first 2 years following diagnosis.
View Article and Find Full Text PDFInfect Dis Clin Microbiol
December 2024
Department of Anesthesiology and Critical Care Unit, Başkent University School of Medicine, Ankara, Türkiye.
Am J Case Rep
January 2025
Department of Behavioral Medicine and Psychiatry, Rockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
BACKGROUND The incidence of drug-induced infectious endocarditis is rapidly rising in the United States. Healthcare providers face different challenges in the management of infectious endocarditis in persons who inject drugs, including addiction relapse, non-compliance with treatment, and the associated social stigma. These factors collectively complicate the management of drug-induced endocarditis, requiring comprehensive strategies that address both the medical condition and the underlying substance use disorder, as well as socio-behavioral aspects of patient care.
View Article and Find Full Text PDFEur J Intern Med
December 2024
Department of Biomedical Sciences, IRCCS Humanitas Research Hospital, 20089 Milano, Italy.
Background And Aim: The aim of the present study was to evaluate the prevalence and to identify the independent predictors of multi-drug resistance among a cohort of patients admitted to emergency department for urinary tract infections (UTI), and to assess the impact of antimicrobial resistance on the clinical outcomes.
Methods: We conducted a prospective multicentre study enrolling all adult patients admitted to one of the eight emergency departments participating in the study with a microbiologically confirmed diagnosis of UTI from February 2023 to July 2024. The primary outcome evaluated was 30-day mortality; secondary outcomes included 7-day mortality and clinical response.
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