Objective: Aim: Determining the characteristics of urinary stone composition in inhabitants of an industrially advanced region afflicted with oxalate and urate urolithiasis.
Patients And Methods: Materials and Methods: A comparative analysis of the morphology of 246 kidney stones from residents of one of heavily industrialized region of Ukraine, was conducted. Petrographic examination of the calculi was performed through microscopic analysis. The qualitative composition of the calculi was investigated using X-ray structural analysis of fragments and dust remnants of the stones, which were formed during the preparation of thin sections.
Results: Results: A distinctive characteristic of all mineral components is their varying microblock structure and the presence of organic material inclusions. The inclusion of an organic component reduces the strength of the crystalline layers. Urolith resembles a brittle-hollow environment, which in certain cases allows for the selection of the most effective methods of their destruction (lithotripsy).
Conclusion: Conclusions: A common feature among all mineral components is their diverse microblock structure and the presence of organic inclusions, which diversify the strength characteristics of uroliths. The prior determination of these characteristics allows for the selection of the most ef f ective method for destructive treatment (lithotripsy). The combination of data on the ontogenesis of uroliths, their mineral composition, and the state of the electrolyte balance in the body of a patient with urolithiasis will allow choosing an individually effective method of metaphylaxis of the disease.
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http://dx.doi.org/10.36740/WLek/191325 | DOI Listing |
Nat Med
January 2025
Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Efficacy of sodium-glucose cotransporter 2 inhibitors for kidney stone prevention in nondiabetic patients is unknown. In a double-blind, placebo-controlled, single-center, crossover phase 2 trial, 53 adults (≥18 and <75 years) with calcium (n = 28) or uric acid (UA; n = 25) kidney stones (at least one previous kidney stone event) without diabetes (HbA1c < 6.5%, no diabetes treatment) were randomized to once daily empagliflozin 25 mg followed by placebo or reverse (2 weeks per treatment).
View Article and Find Full Text PDFIntroduction Phosphate ion is common in the core of urinary stones and may initiate stone formation. However, the precise role of phosphate in the initiation of stone formation remains obscure. We assessed the effects of dietary phosphate load on urinary stone risk and phosphate metabolism.
View Article and Find Full Text PDFJ Ren Nutr
December 2024
DONALD Study Center, Nutritional Epidemiology, Institute of Nutrition and Food Science, University of Bonn, Dortmund, Germany. Electronic address:
Objective: Uromodulin is the most abundant urinary protein in healthy subjects which under physiological conditions protects against kidney stone formation. Acid-base imbalances, especially states with acidic urine, increase the risk for uric acid and oxalate stones, but lower it for phosphate-containing stones. Whether habitual high acid loads and high dietary phosphorus intake (P-In) themselves may influence plasma uromodulin concentrations in the long-term is not known.
View Article and Find Full Text PDFArch Esp Urol
November 2024
Department of Urology, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 05355 Seoul, Korea.
Sci Rep
December 2024
Department of Urology, Qinghai University Affiliated Hospital, Xining, 810000, China.
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