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Maternal mortality in Italy estimated by the Italian Obstetric Surveillance System.
Sci Rep
December 2024
National Centre for Diseases Prevention and Health Promotion, Istituto Superiore di Sanità, Rome, Italy.
This study aimed to calculate Italy's first national maternal mortality ratio (MMR) through an innovative record-linkage approach within the enhanced Italian Obstetric Surveillance System (ItOSS). A record-linkage retrospective cohort study was conducted nationwide, encompassing all women aged 11-59 years with one or more hospitalizations related to pregnancy or pregnancy outcomes from 2011 to 2019. Maternal deaths were identified by integrating data from the Death Registry and national and regional Hospital Discharge Databases supported by the integration of findings from confidential enquiries conducted through active surveillance.
View Article and Find Full Text PDFWeb application using machine learning to predict cardiovascular disease and hypertension in mine workers.
Sci Rep
December 2024
Department of Applied Mathematics, Faculty of Mathematical Science, Ferdowsi University of Mashhad, Mashhad, Iran.
This study presents a web application for predicting cardiovascular disease (CVD) and hypertension (HTN) among mine workers using machine learning (ML) techniques. The dataset, collected from 699 participants at the Gol-Gohar mine in Iran between 2016 and 2020, includes demographic, occupational, lifestyle, and medical information. After preprocessing and feature engineering, the Random Forest algorithm was identified as the best-performing model, achieving 99% accuracy for HTN prediction and 97% for CVD, outperforming other algorithms such as Logistic Regression and Support Vector Machines.
View Article and Find Full Text PDFBAY 2413555 is a novel selective and reversible positive allosteric modulator of the type 2 muscarinic acetylcholine (M2) receptor, aimed at enhancing parasympathetic signaling and restoring cardiac autonomic balance for the treatment of heart failure (HF). This study tested the safety, tolerability and pharmacokinetics of this novel therapeutic option. REMOTE-HF was a multicenter, double-blind, randomized, placebo-controlled, phase Ib dose-titration study with two active arms.
View Article and Find Full Text PDFOxidized phospholipid and transcriptomic signatures of THC-related vaping associated lung injury.
Sci Rep
December 2024
Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
E-cigarette/vaping-associated lung injury (EVALI) is strongly associated with vitamin E acetate and often occurs with concomitant tetrahydrocannabinol (THC) use. To uncover pathways associated with EVALI, we examined cytokines, transcriptomic signatures, and lipidomic profiles in bronchoalveolar lavage fluid (BALF) from THC-EVALI patients. At a single center, we prospectively enrolled mechanically ventilated patients with EVALI from THC-containing products (N = 4) and patients with non-vaping acute lung injury and airway controls (N = 5).
View Article and Find Full Text PDFOxidative potential and persistent free radicals in dust storm particles and their associations with hospitalization.
Nat Commun
December 2024
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
Sand and dust storms (SDS) can cause adverse health effects, with the oxidative potential (OP) and environmentally persistent free radicals (EPFRs) inducing oxidative stress. We mapped the OP and EPFRs concentrations at 1735 sites in China during SDS periods using experimental data for 2021-2023 and a random forest model. We examined 855,869 hospitalizations during SDS events for 2015-2022 in Beijing, China.
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