Background And Aims: Previous results of the Dermatology-Life-Quality-Index (DLQI) validation in Colombia based on the classical test theory (CTT) perspective have showed the need to delve into its measurement properties. Therefore, we aimed to assess the structural validity, internal consistency and item response analysis of the DLQI through the item response theory (IRT) or the Rasch model.
Material And Methods: We assessed the dimensionality of the DLQI, determined its difficulty, discrimination and differential functioning and went on to evaluate its internal consistency and discriminative validity among patients with inflammatory and non-inflammatory skin disease. We recruited Colombian patients with different skin diseases.
Results: Data of 865 patients (mean age, 49.3 years; 61% females) were included. DLQI-scores ranged from 0 up to 30. Internal consistency for dichotomous item #7 showed a McDonald's Omega coefficient of 0.85 (95%CI, 0.84-0.87) and a Cronbach's α coefficient of 0.86 (95%CI, 0.84-0.88). For ordinal item #7, the McDonald's Omega coefficient was 0.87 (95%IC: 0.85-0.89) and Cronbach's α coefficient, 0.84 (95%CI, 0.82-0.87). Horn's parallel analysis revealed the presence of DLQI unidimensionality with a 1-factor solution. Only item #1 fitted the PCM model. The remaining items, including item #9, did not show adequate fit due to overlapping responses and order changes.
Conclusions: The validity of DLQI-COL based on Rasch analysis proved not to be a suitable instrument to evaluate QoL in our dermatologic population. A refined version of the scale with an adequate cross-cultural adaptation and validation process is needed to obtain an appropriate and reliable version of the instrument for QOL measuring in Colombian patients with skin diseases.
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http://dx.doi.org/10.1016/j.ad.2024.09.020 | DOI Listing |
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National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing, China.
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Institute of Social Medicine and Health Systems Research, Faculty of Medicine, Otto von Guericke University, Magdeburg, Germany.
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Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
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Respir Res
January 2025
Department of Regenerative and Infectious Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama Chuo-ku, Hamamatsu, Shizuoka, 431-3192, Japan.
Background: Recent advances in comprehensive gene analysis revealed the heterogeneity of mouse lung fibroblasts. However, direct comparisons between these subpopulations are limited due to challenges in isolating target subpopulations without gene-specific reporter mouse lines. In addition, the properties of lung lipofibroblasts remain unclear, particularly regarding the appropriate cell surface marker and the niche capacity for alveolar epithelial cell type 2 (AT2), an alveolar tissue stem cell.
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