Sleep Med
Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Paediatrics, Faculty of Medicine, University of Toronto, Ontario, Canada; Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address:
Published: December 2024
Background: The underlying mechanism for the association between sleep restriction (SR) and unfavorable cognitive outcomes in children and adolescents remains unclear. This study aimed to understand the effect of 5-night experimental SR on magnetic resonance imaging (MRI) measurements of cerebrovascular reactivity (CVR) and cognitive function in adolescents.
Methods: This randomized crossover study compared two sleep conditions, SR and Control Sleep (CS) in a home setting. Healthy adolescents aged 15-18 years were recruited. The protocol began with two nights of baseline sleep to record participants' habitual sleep duration, followed by the two sleep conditions in the randomly allocated sequence, either SR (6 h in bed for 5 nights) followed by CS (9 h in bed for 5 nights), or the reverse sequence. Their sleep-wake pattern was monitored by an accelerometer and a sleep diary throughout the study period. Cerebral hemodynamics were assessed by hypercapnic challenge blood oxygen level-dependent (BOLD) MRI of CVR. Cognitive function was evaluated by NIH Toolbox Cognitive Battery on the day immediately after each sleep condition.
Results: A total of 27 participants (8 males; mean age: 16.8 ± 0.7 years, range 15-18 years) were included in the study. The average sleep duration was significantly reduced in the SR condition compared to the CS condition (320 ± 34 min vs. 426 ± 45 min, p < 0.001). The CVR in the temporal occipital fusiform cortex [adjusted β(95 % CI) = -0.091(-0.010 to -0.172), p = 0.032] and occipital lobe [adjusted β(95 % CI) = -0.087 (-0.002 to -0.172), p = 0.045] was significantly lower following the SR condition when compared to the CS condition. Participants also had lower performance scores in the inhibitory control [adjusted β(95 % CI) = -6.0(-0.9 to -11.0), p = 0.019] and cognitive flexibility [adjusted β(95 % CI) = -6.6 (-1.7 to -11.6), p = 0.008] domains after the SR condition when compared to the CS condition.
Conclusions: Short-term SR is associated with poorer cognitive function possibly through reduced cerebral vasodilatory capacity in specific cognitive regions.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.sleep.2024.11.005 | DOI Listing |
J Am Coll Health
January 2025
Department of Psychology, University of St. Thomas, St. Paul, Minnesota, USA.
Objective: To determine the direct and indirect effects of sexual assault on sleep health in varsity athletes.
Participants: Varsity athletes ( = 2,910) who completed the Fall 2019 or 2020 administrations of the American College Health Association's National College Health Assessment III.
Methods: We combined exploratory factor analysis and structural equation modeling to evaluate relationships between four predictor variables: and and two response variables: and
Results: Overall, 9.
Medicine (Baltimore)
January 2025
Pediatrics Department, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, Gansu, China.
This retrospective study aims to assess the adjunctive efficacy of warm needle moxibustion and gua sha care in the treatment of eszopiclone tablets on sleep quality and psychological stress in insomnia patients. Data of 138 insomnia patients from Gansu Baoshihua hospital between January and December 2022 were collected. Patients were bifurcated into 2 groups: those solely treated with eszopiclone (n = 71) and those administered a combined regimen of eszopiclone, warm needle moxibustion, and gua sha (n = 67).
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Centro Universitario de Enfermería Cruz Roja, University of Seville, Seville, Spain.
Background: There is an increased prevalence of mental health problems in various population groups as a result of the COVID-19 pandemic and its consequences, especially regarding anxiety, stress, depression, fear, and sleep disturbances, require to be investigated longitudinally.
Objective: This study aimed to determine the impact that the COVID-19 pandemic had on the mental health of Nursing students, as well as to examine other associated factors such as anxiety, fear, sleep disturbances, and coping strategies.
Method: This systematic review and meta-analysis were designed following the PRISMA guidelines and were registered in PROSPERO with code CRD42024541904.
Sci Immunol
January 2025
Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Human recombination-activating gene (RAG) deficiency can manifest with distinct clinical and immunological phenotypes. By applying a multiomics approach to a large group of -mutated patients, we aimed at characterizing the immunopathology associated with each phenotype. Although defective T and B cell development is common to all phenotypes, patients with hypomorphic variants can generate T and B cells with signatures of immune dysregulation and produce autoantibodies to a broad range of self-antigens, including type I interferons.
View Article and Find Full Text PDFJ Bronchology Interv Pulmonol
January 2025
Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School.
Background: Open window thoracostomy (OTW) is the standard of care for debilitated patients with chronic pleural infection and nonexpandable lungs (NEL) who are not candidates for major surgical intervention. Tunneled pleural catheters (TPC) offer tremendous treatment potential in this setting based on their efficacy in malignant pleural effusion and NEL. We aim to assess the efficacy, safety, and health care utilization of TPC in this setting.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!
© LitMetric 2025. All rights reserved.