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Automated characterisation of cerebral microbleeds using their size and spatial distribution on brain MRI.
Eur Radiol Exp
January 2025
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
Cerebral microbleeds (CMBs) are small, hypointense hemosiderin deposits in the brain measuring 2-10 mm in diameter. As one of the important biomarkers of small vessel disease, they have been associated with various neurodegenerative and cerebrovascular diseases. Hence, automated detection, and subsequent extraction of clinically useful metrics (e.
View Article and Find Full Text PDFLarge scale event segmentation affects the microlevel action control processes.
J Exp Psychol Gen
January 2025
Department of Psychology, University of Trier.
How do we make sense of our surroundings? A widely recognized field in cognitive psychology suggests that many important functions like memory of incidents, reasoning, and attention depend on the way we segment the ongoing stream of perception (Zacks & Swallow, 2007). An open question still is, how the structure generated from a perceptual stream translates into behavior. To address this question, we combined the findings in event segmentation literature with another influential body of literature that analyzes mechanisms behind the control of individual actions (Frings et al.
View Article and Find Full Text PDFDeciphering the endogenous SUMO-1 landscape: a novel combinatorial peptide enrichment strategy for global profiling and disease association.
Chem Sci
December 2024
State Key Laboratory of Medical Proteomics, National Chromatographic R. & A. Center, CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 P. R. China
Small ubiquitin-like modifier (SUMO) plays a pivotal role in diverse cellular processes and is implicated in diseases such as cancer and neurodegenerative disorders. However, large-scale identification of endogenous SUMO-1 faces challenges due to limited enrichment methods and its lower abundance compared to SUMO-2/3. Here we propose a novel combinatorial peptide strategy, combined with anti-adhesive polymer development, to enrich endogenous SUMO-1 modified peptides, revealing a comprehensive SUMOylation landscape.
View Article and Find Full Text PDFWeakly supervised pathological differentiation of primary central nervous system lymphoma and glioblastoma on multi-site whole slide images.
J Med Imaging (Bellingham)
January 2025
Shandong Provincial Hospital Affiliated to Shandong First Medical University, Department of Neurosurgery, Jinan, China.
Purpose: Differentiating primary central nervous system lymphoma (PCNSL) and glioblastoma (GBM) is crucial because their prognosis and treatment differ substantially. Manual examination of their histological characteristics is considered the golden standard in clinical diagnosis. However, this process is tedious and time-consuming and might lead to misdiagnosis caused by morphological similarity between their histology and tumor heterogeneity.
View Article and Find Full Text PDFFormation of cognitive maps in large-scale environments by sensorimotor integration.
Cogn Neurodyn
December 2025
School of Systems Science, Beijing Normal University, Beijing, 100875 China.
Hippocampus in the mammalian brain supports navigation by building a cognitive map of the environment. However, only a few studies have investigated cognitive maps in large-scale arenas. To reveal the computational mechanisms underlying the formation of cognitive maps in large-scale environments, we propose a neural network model of the entorhinal-hippocampal neural circuit that integrates both spatial and non-spatial information.
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