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An exceptionally rare case of a diffuse midline glioma with concomitant H3.1 K27M and G34R mutations in the HIST1H3C (H3C3) gene.
Acta Neuropathol Commun
January 2025
Institute of Cancer Research, London, UK.
Histone mutations (H3 K27M, H3 G34R/V) are molecular features defining subtypes of paediatric-type diffuse high-grade gliomas (HGG) (diffuse midline glioma (DMG), H3 K27-altered, diffuse hemispheric glioma (DHG), H3 G34-mutant). The WHO classification recognises in exceptional cases, these mutations co-occur. We report one such case of a 2-year-old female presenting with neurological symptoms; MRI imaging identified a brainstem lesion which was biopsied.
View Article and Find Full Text PDFPrognostic value of immunohistochemical staining for H3K27me3 and EZH2 in astrocytoma, IDH-mutant.
J Neurooncol
December 2024
Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima, 734-8551, Japan.
Article Synopsis
- H3K27 trimethylation (H3K27me3), regulated by EZH2, plays a critical role in gene expression and is a key diagnostic marker for certain brain tumors, but its implications in astrocytoma with IDH mutation are unclear.
- A study involving 33 patients analyzed the correlation between immunohistochemical markers (including H3K27me3, EZH2) and patient outcomes like overall survival (OS) and progression-free survival (PFS).
- Results indicated that H3K27me3 positivity, particularly when combined with EZH2 positivity, was associated with poorer survival rates, suggesting it may serve as a significant prognostic factor for astrocytoma, IDH
Correction to: Positive H3K27M cytology in cerebrospinal fluid in diffuse midline glioma.
Neurol Sci
November 2024
Department of Neurology and Neurological Science, Institute of Science, Tokyo, Japan.
Positive H3K27M cytology in cerebrospinal fluid in diffuse midline glioma.
Neurol Sci
November 2024
Department of Neurology and Neurological Science, Institute of Science, Tokyo, Japan.
Primary spinal cord gliomas: Pathologic features associated with prognosis.
J Neuropathol Exp Neurol
December 2024
Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.
Primary spinal cord gliomas are rare and are associated with high mortality. Unlike brain tumors, the clinicopathological features of spinal cord gliomas are not well defined. We analyzed clinical, histopathology, and immunohistochemical features and overall survival (OS) of 25 patients with primary spinal cord gliomas treated between 1994 and 2023 at 4 institutions.
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