AI Article Synopsis
- Researchers have developed a quick and efficient method to create CF-phenanthridones using 4-methyl-3-trifluoroacetylquinolones and nitro-olefins through a special chemical reaction called benzannulation.
- This new method is better than previous ones because it only requires a basic substance and doesn't depend on complicated metal catalysts or oxidants.
- The presence of the strong electron-withdrawing CF group in the quinolone helps to form a reactive intermediate that drives the reaction forward.
Article Abstract
Herein, we report a mild, efficient, and rapid approach for the preparation of CF-phenanthridones through a cross-conjugated vinylogous [4 + 2] benzannulation of easily accessible 4-methyl-3-trifluoroacetylquinolones and nitro-olefins. The present transformation is superior to previous approaches for obtaining CF-phenanthridones, in that it proceeds exclusively with the assistance of a simple base, eliminating the need for transition metal catalysts or oxidants. The strong electron-withdrawing nature of the CF-group present in the quinolone moiety promotes the formation of a reactive cross-conjugated vinylogous enolate.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/d4ob01480d | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!