AI Article Synopsis

  • Cadherin 2 (CDH2) and Cadherin 13 (CDH13) significantly influence the progression and prognosis of various cancers, but their specific roles in adrenocortical carcinoma (ACC) are not well understood.
  • In a study of 75 ACC patients, CDH2 was found to be downregulated and CDH13 upregulated, affecting patient prognosis and showing a complex network of interactions with neighboring genes related to tumor development and metabolism.
  • Moreover, CDH13 expression correlated positively with immune cell infiltration in ACC, and treatments like anti-PD1 immunotherapy were shown to alter its expression; thus, CDH2 and CDH13 may be viable targets for

Article Abstract

Cadherin 2 (CDH2, N-cadherin) and cadherin 13 (CDH13, T-cadherin, H-cadherin) affect the progress and prognoses of many cancers. However, their roles in adrenocortical carcinoma (ACC), a rare endocrine cancer, remain unclear. To decipher the roles of these proteins in ACC and to identify their regulatory targets, we analyzed their expression levels, gene regulatory networks, prognostic value, and targets in ACC, using various bioinformatic analyses. was strongly downregulated and was strongly upregulated in patients with ACC; the expression levels of these genes affected the prognosis. In 75 patients, the expression of and was altered by 8% and 5%, respectively. and , as well as their neighboring genes, were predicted to form a complex network of interactions, mainly through coexpression and physical and genetic interactions. and its altered neighboring genes (ANGs) mainly affect tumor-related gene expression, cell cycle, and energy metabolism. The regulation of tumor-related integrin function, gene transcription, metabolism, and amide and phospholipid metabolism are the main functions of and its ANGs. MiRNA and kinase targets of and in ACC were identified. expression in patients with ACC was positively associated with immune cell infiltration. Anti-PD1/CTLA-4/PD-L1 immunotherapy significantly downregulated the expression of in patients with ACC. Foretinib and elesclomol were predicted to exert strong inhibitory effects on SW13 cells by inhibiting the expression of and . These data indicate that CDH2 and CDH13 are promising targets for precise treatment of ACC and may serve as new biomarkers for ACC prognosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572284PMC
http://dx.doi.org/10.1080/15384047.2024.2428469DOI Listing

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