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Genetic and Clinical-epidemiologic Profile of hRSV in Pediatric Patients in Southern Brazil: A Four-year Hospital Surveillance Study.
Pediatr Infect Dis J
December 2024
Public Health Laboratory, Secretaria de Saúde do Estado do Paraná, Curitiba, Brazil.
Background: Respiratory syncytial virus (hRSV) infections primarily cause acute respiratory illness and pediatric hospitalizations. We examined the hRSV molecular epidemiology in a pediatric cohort over a 4-year period and described the interrelationship with clinical data.
Methods: A cross-sectional study was conducted from 2014 to 2017 on children with acute respiratory illness.
Epidemiological characteristics of eleven common respiratory viral infections in children.
BMC Pediatr
December 2024
Department of Pediatrics, Yan'an University Affiliated Hospital, Yan'an, 716000, China.
Background: Lower respiratory tract infections (LRTIs) are one of the leading causes of hospital admissions among children. In this study, we aimed to describe the epidemiological characteristics of viral pathogens associated with LRTIs in hospitalized children in Yan'an; this has yet to be reported in the literature and may guide public health interventions and resource allocation in this region.
Methods: Between June 2021 and May 2023, we conducted a retrospective analysis of the results of viral detection using oral pharyngeal swabs from 4565 children with LRTIs in the Inpatient Department of Yan'an University Affiliated Hospital.
Protective effect of interferon type I on barrier function of human airway epithelium during rhinovirus infections in vitro.
Sci Rep
December 2024
Department of Respiratory Medicine and Allergology, Medical Clinic 1, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
The airway epithelium provides a crucial barrier against infection with respiratory pathogens. This barrier can be impaired following viral infection, paving the way for bacterial superinfections. Type I interferons (IFNs) are important antiviral mediators, and inhaled formulations of these glycoproteins are considered a potential approach for the treatment of respiratory viral infections.
View Article and Find Full Text PDFPrecision Diagnosis of Viral Respiratory Infections: Unleashing the Power of Multiplex Polymerase Chain Reaction (PCR) for Enhanced Infection Management.
Cureus
November 2024
Microbiology, All India Institute of Medical Sciences, Rishikesh, Rishikesh, IND.
Background: Viruses are key agents causing respiratory illnesses, creating significant public health challenges worldwide. Timely identification of the responsible pathogen is crucial for effective patient management. Conventional virus detection methods in laboratories are often laborious and time-consuming, prompting the need for more efficient diagnostic techniques.
View Article and Find Full Text PDFChildhood Respiratory Illnesses Before and After COVID-19 Pandemic Restrictions.
Cureus
November 2024
Pediatric Emergency Medicine, Loma Linda University Medical Center, Loma Linda, USA.
Introduction With the COVID-19 pandemic, multiple studies described a significant drop in common respiratory viruses in children with the lockdown and restrictions. With the lifting of pandemic precautions, we had the ability to observe new patterns of respiratory illnesses in children and emergency department visits. Materials and methods We studied all respiratory nucleic acid amplification test results in emergency patients from a large metropolitan children's hospital from the years 2018 to 2023.
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