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| http://dx.doi.org/10.1002/cl2.70010 | DOI Listing |
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Digital Health Intervention (SANGYAN Podcast) to Enhance Knowledge Related to COVID-19 and Other Health Conditions: Protocol for an Implementation and Evaluation Study.
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January 2025
Foundation of Healthcare Technologies Society, New Delhi, India.
Background: Podcasts are an unconventional method of disseminating information through audio to the masses. They are an emerging portable technology and a valuable resource that provides unlimited access for promoting health among participants. Podcasts related to health care have been used as a source of medical education, but there is a dearth of studies on the use of podcasts as a source of health information.
View Article and Find Full Text PDFThe current understanding of humoral immune response in cancer patients suggests that tumors may be infiltrated with diffuse B cells of extra-tumoral origin or may develop organized lymphoid structures, where somatic hypermutation and antigen-driven selection occur locally. These processes are believed to be significantly influenced by the tumor microenvironment through secretory factors and biased cell-cell interactions. To explore the manifestation of this influence, we used deep unbiased immunoglobulin profiling and systematically characterized the relationships between B cells in circulation, draining lymph nodes (draining LNs), and tumors in 14 patients with three human cancers.
View Article and Find Full Text PDFAn X-Linked Ataxia Syndrome in a Family with Hearing Loss Associated with a Novel Variant in the BCAP31 Gene.
Mov Disord
January 2025
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Objective: Pathogenic variants in B-cell receptor-associated protein (BCAP31) are associated with X-linked, deafness, dystonia and cerebral hypomyelination (DDCH) syndrome. DDCH is congenital and non-progressive, featuring severe intellectual disability (ID), variable dysmorphism, and sometimes associated with shortened survival. BCAP31 encodes one of the most abundant chaperones, with several functions including acting as a negative regulator of endoplasmic reticulum (ER) calcium ion (Ca) concentration.
View Article and Find Full Text PDFConsensus statement for the diagnosis, treatment, and prognosis of kaposiform hemangioendothelioma.
Int J Cancer
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Division of Oncology, Department of Pediatric Surgery, and Rare Diseases Center, West China Hospital, Sichuan University, China.
Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor that typically presents in infancy or early childhood. As awareness of KHE increases, it is imperative that the management of KHE be updated to reflect the latest evidence-based guidelines. The aim of this study was to integrate the literature and Chinese expert opinions to provide updated recommendations that will guide the diagnosis, treatment, and prognosis of patients with KHE.
View Article and Find Full Text PDFChild Death and Mothers' Subsequent Mental Health in a High-Mortality African Community.
Popul Dev Rev
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Partners in Hope, Lilongwe, Malawi.
Despite declines in child mortality rates, experiencing a child death remains a common feature of motherhood in many contemporary African populations. Yet, we lack population insights into the consequences of child death for mothers' well-being in the high-mortality regions where it concentrates. Contrasting an extensive psychology literature on the severe and long-lasting consequences of child death for parents in low-mortality settings, a long-standing thesis in multiple social science literature is that the normativity of child death in high-mortality settings can lead to a numbing effect-muting parents' reactions to child loss.
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