Mechanical heart valve replacements are highly durable and effective but come with a substantial requirement for lifelong anticoagulation therapy to prevent thromboembolic complications. Unlike biological valve replacements, which typically require less rigorous anticoagulation, mechanical valves - particularly in the aortic and mitral positions - present a higher risk for clot formation, necessitating strict adherence to anticoagulation regimens. This case report examines a 59-year-old male with double mechanical heart valve replacements who experienced poor compliance with anticoagulation therapy for over 30 years, ultimately leading to significant health complications. Despite his long-standing non-compliance, the patient initially avoided severe thromboembolic events until he suffered a stroke in 2022, followed by the onset of severe heart failure due to persistent suboptimal anticoagulation. His case is unique, given the prolonged lack of adherence to anticoagulation therapy, and highlights the critical need for consistent anticoagulation management in patients with mechanical heart valves. We explore the challenges of managing anticoagulation in complex cases and underscore the importance of consistent adherence to anticoagulation therapy, multidisciplinary intervention, and patient education in improving patient outcomes.
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http://dx.doi.org/10.7759/cureus.73611 | DOI Listing |
PLoS One
December 2024
Department of Radiology, Columbia University, New York, NY, United States of America.
Background: Imaging both electrical and mechanical cardiac function can better characterize cardiac disease and improve patient care. Currently, there is no noninvasive technique that can simultaneously image both electrical and mechanical function of the whole heart at the point of care. Here, our aim is to demonstrate that high volume-rate echocardiography can simultaneously map cardiac electromechanical activation and end-systolic cardiac strain of the whole heart in a single heartbeat.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
December 2024
Department of Surgery, University of Toronto, Toronto, ON M5S 1A1, Canada.
Background: The most common cause of death in patients with peripheral artery disease (PAD) are major adverse cardiovascular events (MACEs), including myocardial infarction (MI) and stroke. However, data on biomarkers that could be used to help predict MACEs in patients with PAD to guide clinical decision making is limited. Angiogenesis-related proteins have been demonstrated to play an important role in systemic atherosclerosis and may act as prognostic biomarkers for MACEs in patients with PAD.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
December 2024
3rd Department of Cardiology, "Sotiria" Chest Diseases Hospital, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Hypertrophic cardiomyopathy (HCM) is a complex and heterogeneous cardiac disorder, often complicated by cardiogenic shock, a life-threatening condition marked by severe cardiac output failure. Managing cardiogenic shock in HCM patients presents unique challenges due to the distinct pathophysiology of the disease, which includes dynamic left ventricular outflow tract obstruction, diastolic dysfunction, and myocardial ischemia. This review discusses current and emerging therapeutic strategies tailored to address the complexities of HCM-associated cardiogenic shock and other diseases with similar pathophysiology that provoke left ventricular outflow tract obstruction.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
December 2024
Faculty of Medicine & Health Sciences, University of Antwerp, 2610 Antwerp, Belgium.
The need for a permanent pacemaker (PPM) implantation after surgical aortic valve implantation (SAVR) is a recognized postoperative complication, with potentially long-term reduced survival. From 1987 to 2017, 2500 consecutive patients underwent SAVR with a biological valve with or without concomitant procedures such as CABG or mitral valve repair. Mechanical valves or valves in another position were excluded.
View Article and Find Full Text PDFJ Cardiovasc Dev Dis
December 2024
Cardiovascular Section, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27101, USA.
: Fatal coronary heart disease (FCHD) affects ~650,000 people yearly in the US. Electrocardiographic artificial intelligence (ECG-AI) models can predict adverse coronary events, yet their application to FCHD is understudied. : The study aimed to develop ECG-AI models predicting FCHD risk from ECGs.
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