Purpose: This study aimed to evaluate the comfort and discomfort of two types of soft contact lenses (SCLs) by comparing their quality of vision, fit, subjective dryness, and handling.
Methods: A total of 62 SCL wearers with contact lens (CL) discomfort were recruited. They were fitted with narafilcon A and verofilcon A for two weeks each by crossover. The comfort of the two types of SCLs was compared by having each participant answer a modified 5-Item Dry Eye Questionnaire (m-DEQ5, scores for vision, wearing comfort, and handling: the total score of the five items is a maximum of 25, higher being better) and modified Japanese version of the 8-item Contact Lens Dry Eye Questionnaire (m-J-CLDEQ-8: scores for discomfort and dry eye symptoms: the total score of the eight items is a maximum of 44; lower is better) survey forms. Results Overall, the m-DEQ5 and m-J-CLDEQ-8 scores for the two SCLs of narafilcon A and verofilcon A were higher than the median of 3.0 points. Scores for 4 of 5 items and total scores in m-DEQ5 (18.7 ± 3.4 vs. 21.6 ± 2.5) were significantly higher and better in verofilcon A than in narafilcon A (p<0.01). Scores for 8 of 8 items and total scores on the m-J-CLDEQ-8 (15.2 ± 7.9 vs. 8.4 ± 4.9) were also significantly lower and better in verofilcon A than in narafilcon A (p<0.05).
Conclusion: Verofilcon A provided excellent vision, comfort, and ease of handling and was less likely to cause dry eye symptoms or eye discomfort. These results suggest that verofilcon A is an excellent option for patients with dry eye symptoms and CL discomfort.
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http://dx.doi.org/10.7759/cureus.71553 | DOI Listing |
Cont Lens Anterior Eye
January 2025
Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; Department of Integrative Medicine, Baoshan Campus of Huashan Hospital, Fudan University, Shanghai, China. Electronic address:
Purpose: To investigate the efficacy and safety of transient receptor potential (TRP) channel modulators for dry eye.
Methods: A thorough search for randomized clinical trials was conducted in seven databases up to February 16, 2024. Suitable studies were identified according to inclusion and exclusion criteria, extracted data were synthesized and analyzed using Review Manager 5.
Expert Opin Drug Saf
January 2025
Eye Institute & Affiliated Xiamen Eye Center, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Background: Dry eye syndrome (DES) has become a significant public health issue, impacting quality of life. Meibomian Gland Dysfunction (MGD) is a primary contributor to DES, and its etiology includes diverse factors. Given the potential for drug-induced MGD, comprehensive investigation into this association is crucial.
View Article and Find Full Text PDFArthritis Res Ther
January 2025
Scientific Research Project Department, Guangdong Artificial Intelligence and Digital Economy Laboratory (Guangzhou), Pazhou Lab, Guangzhou, China.
Background: Primary Sjogren's syndrome (pSS) and autoimmune thyroiditis (AIT) share overlapping genetic and immunological profiles. This retrospective study evaluates the efficacy of machine learning algorithms, with a focus on the Random Forest Classifier, to predict the presence of thyroid-specific autoantibodies (TPOAb and TgAb) in pSS patients.
Methods: A total of 96 patients with pSS were included in the retrospective study.
Nat Commun
January 2025
Rheumatology Research Group, Department of Inflammation and Ageing, College of Medicine & Health, University of Birmingham, Birmingham, UK.
Tertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have been identified, the cellular sources and temporal and spatial relationship remain unknown. Here we use combine single-cell RNA-sequencing, spatial transcriptomics and proteomics of minor salivary glands of patients with Sjogren's disease and Sicca Syndrome, with ex-vivo functional studies to construct a cellular and spatial map of key components involved in the formation and function of tertiary lymphoid structures.
View Article and Find Full Text PDFOcul Surf
December 2024
The First Hospital Affiliated to Heilongjiang University of Chinese Medicine, Harbin, China, 150040. Electronic address:
Dry eye disease (DED) is a multifactorial condition with complex and incompletely understood molecular mechanisms. Advances in multi-omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and microbiomics, have provided new insights into the pathophysiology of DED. Genomic analyses have identified key genetic variants linked to immune regulation and lacrimal gland function.
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