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Large Scale Ultrafast Manufacturing of Wireless Soft Bioelectronics Enabled by Autonomous Robot Arm Printing Assisted by a Computer Vision-Enabled Guidance System for Personalized Wound Healing. | LitMetric

AI Article Synopsis

  • - A new system called CARE (Customized wound patch for Advanced tissue Regeneration with Electric field) uses an autonomous robot arm and computer vision to quickly create flexible and wireless bioelectronic patches for wound treatment.
  • - The system includes a 6-axis robot arm that scans wounds from multiple angles to create a detailed 3D map, and its design is optimized using MATLAB simulations for efficient wireless power delivery.
  • - In lab tests, CARE can stimulate healing in wounds up to 10 mm deep, showing significant improvements in cell migration rates, indicating its potential as an effective clinical wound therapy solution.

Article Abstract

A Customized wound patch for Advanced tissue Regeneration with Electric field (CARE), featuring an autonomous robot arm printing system guided by a computer vision-enabled guidance system for fast image recognition is introduced. CARE addresses the growing demand for flexible, stretchable, and wireless adhesive bioelectronics tailored for electrotherapy, which is suitable for rapid adaptation to individual patients and practical implementation in a comfortable design. The visual guidance system integrating a 6-axis robot arm enables scans from multiple angles to provide a 3D map of complex and curved wounds. The size of electrodes and the geometries of power-receiving coil are essential components of the CARE and are determined by a MATLAB simulation, ensuring efficient wireless power transfer. Three heterogeneous inks possessing different rheological behaviors can be extruded and printed sequentially on the flexible substrates, supporting fast manufacturing of large customized bioelectronic patches. CARE can stimulate wounds up to 10 mm in depth with an electric field strength of 88.8 mV mm. In vitro studies reveal the ability to accelerate cell migration by a factor of 1.6 and 1.9 for human dermal fibroblasts and human umbilical vein endothelial cells, respectively. This study highlights the potential of CARE as a clinical wound therapy method to accelerate healing.

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Source
http://dx.doi.org/10.1002/adhm.202401735DOI Listing

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