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Unveiling the fibrotic puzzle of endometriosis: An overlooked concern calling for prompt action.
F1000Res
December 2024
Division of Reproductive Biology, Department of Reproductive Science, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Endometriosis is a benign, estrogen-dependent, persistent chronic inflammatory heterogeneous condition that features fibrotic adhesions caused by periodic bleeding. The characteristic ectopic lesions are marked by a widely spread dense fibrotic interstitium comprising of fibroblasts, myofibroblasts, collagen fibers, extracellular proteins, inflammatory cells, and active angiogenesis. Fibrosis is now recognized as a critical component of endometriosis because of which current treatments, such as hormonal therapy and surgical excision of lesions are largely ineffective with severe side effects, high recurrence rates, and significant morbidity.
View Article and Find Full Text PDFRe: Adhesive Anti-fibrotic Interfaces on Diverse Organs.
Eur Urol
November 2024
Department of Urology, Medical University of Vienna, Vienna, Austria; Department of Urology, 2nd Faculty of Medicine, Hospital Motol, Charles University, Prague, Czechia; Department of Urology, Weill Cornell Medical College, New York, NY, USA; Department of Urology, University of Texas Southwestern, Dallas, TX, USA; Hourani Center for Applied Scientific Research, Al-Ahliyya Amman University, Amman, Jordan.
New Insights into the Pleiotropic Actions of Dipeptidyl Peptidase-4 Inhibitors Beyond Glycaemic Control.
touchREV Endocrinol
October 2024
Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Dipeptidyl peptidase-4 (DPP-4) is a multifunctional serine ectopeptidase that cleaves and modifies a plethora of substrates, including regulatory peptides, cytokines and chemokines. DPP-4 is implicated in the regulation of immune response, viral entry, cellular adhesion, metastasis and chemotaxis. Regarding its numerous substrates and extensive expression inside the body, multitasking DPP-4 has been assumed to participate in different pathophysiological mechanisms.
View Article and Find Full Text PDFHypericum Perforatum Callus Extract-Loaded Composite Hydrogel with Diverse Bioactivities for Enhanced Wound Healing and Fibrosis Prevention.
Small
December 2024
Department of Civil and Mechanical Engineering, Technical University of Denmark, Kongens Lyngby, 2800, Denmark.
Article Synopsis
- Plant callus, particularly from Hypericum perforatum, is rich in beneficial compounds like hyperforin and hypericin that have antibacterial and anti-inflammatory properties, making them useful for wound healing.
- A new wound dressing made from poly(vinyl alcohol), chitosan, and alginate is infused with Hypericum perforatum callus extract (HPCE) and has shown favorable properties such as high swelling capacity and mechanical strength, enhancing tissue regeneration.
- In laboratory and animal studies, this dressing has been proven to be biocompatible, promote healing processes like re-epithelialization and collagen deposition, and reduce the risk of fibrosis after wounds heal, while also combating antibiotic-resistant bacteria.
Therapeutic role of physalin A in the pathogenesis of Graves' orbitopathy.
Immunopharmacol Immunotoxicol
December 2024
Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Background: Graves' orbitopathy (GO) is an autoimmune condition that causes serious ocular symptoms; its treatment strategies are limited. Physalin A is a phytosterol that has shown various therapeutic properties, including anti-inflammatory and anti-fibrotic effects. In this study, we investigated whether physalin A could inhibit inflammation, fibrosis, hyaluronan (hyaluronic acid) production, and adipogenesis, which are crucial to the pathogenesis of GO.
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