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Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Byrd Alzheimer's Center & Research Institute, Tampa, FL, USA.
Background: Microglia play significant roles in Alzheimer's disease (AD) pathophysiology. Current evidence suggests microglia may function in both protective and degenerative capacities, which has received little clarity from transcriptionally-characterised phenotypes uncovered from transgenic pathologies alone. BIN1 - the second-most significant risk gene for the development of late-onset AD (LOAD) - is expressed at high levels in neurons, oligodendrocytes and microglia.
View Article and Find Full Text PDFInvestigation and Analysis of Disaster Preparedness among Nurses in Chinese Non-First-tier (Inland) Cities: A Case Study from Yongcheng City, Henan Province.
Disaster Med Public Health Prep
January 2025
Department of Neurosurgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai200120, China.
Objectives: Compared with first-tier cities in China that are of abundant funds and resources like legions of high-level hospitals, the degree of nurses' disaster nursing preparedness in non-first-tier cities (inland) is relatively lower. For example, nurses' knowledge reserve of specific disasters is not comprehensive enough. And nurses are diffident when it comes to the skills of handling disaster rescue.
View Article and Find Full Text PDFIt's dark under the lamp? The moderating role of executives' accounting competence on relationship between goodwill impairment signal and goodwill impairment.
PLoS One
January 2025
Business School of Sichuan Normal University, Chengdu, Sichuan Province, China.
This study examines the influence of executives' accounting competence on relationship between goodwill impairment signal and goodwill impairment, considering the perspective of performance compensation commitment. The research employs an empirical research method and utilizes a sample of A-share listed companies in China that have signed performance compensation commitment agreements from 2007 to 2022. I found that the executives' accounting competence weakens the relationship between goodwill impairment signal and goodwill impairment.
View Article and Find Full Text PDF"It's a delicate balance": clinicians' experiences of providing heroin-assisted treatment.
Harm Reduct J
December 2024
Unit for Clinical Research on Addictions, Oslo University Hospital Health Trust, PB 4959 Nydalen, Oslo, 0424, Norway.
Background: Little attention has been paid to the experiences of clinicians and health personnel who provide heroin-assisted treatment (HAT). This study provides the first empirical findings about the clinicians' experiences of providing HAT in the Norwegian context.
Methods: 23 qualitative interviews were conducted with 31 clinicians shortly after HAT clinics opened in Norway's two largest cities: Oslo and Bergen.
Genome-wide characterization of the WRKY gene family and the role of LsfWRKY29 in regulating somatic embryogenesis in hybrid sweetgum (Liquidambar styraciflua × L. formosana).
Int J Biol Macromol
December 2024
State Key Laboratory of Tree Genetics and Breeding, National Engineering Research Center of Tree Breeding and Ecological Restoration, Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants, Ministry of Education, The Tree and Ornamental Plant Breeding and Biotechnology Laboratory of National Forestry and Grassland Administration, College of Biological Sciences and Biotechnology, Beijing Forestry University, Beijing 100083, China. Electronic address:
Hybrid sweetgum (Liquidambar styraciflua × L. formosana) is a globally significant forest tree resource, exhibiting significant economic, ornamental, ecological and medicinal values. Somatic embryogenesis (SE) is an effective reproductive strategy, having great application potential and economic value in large-scale propagation, artificial seed production, genetic transformation, germplasm preservation and biotechnology.
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