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Beyond anxiety: Autonomy and harm reduction approaches to DIY Hormone Replacement Therapy.
Indian J Med Ethics
January 2025
Assistant Professor of Practice, Centre for Writing & Pedagogy, Krea University; Working Editor, Indian Journal of Medical Ethics, INDIA.
A researcher in a Hyderabad-based science institution, Roshni (name changed to preserve anonymity) started identifying as a transgender woman in 2018, and wanted to start her medical transition - the process by which transgender people seek to affirm and express their gender using medical interventions.
View Article and Find Full Text PDFUnbalanced long-chain fatty acid beta-oxidation in newborns with cystic fibrosis and congenital hypothyroidism.
Mol Genet Metab Rep
March 2025
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
Background: Immediately after birth, adaptation to the extrauterine environment includes an upregulation of fatty acid catabolism. Cystic fibrosis and untreated hypothyroidism exert a life-long impact on fatty acid metabolism, but their influence during this transitional period is unknown. Children and adults with cystic fibrosis exhibit unbalanced fatty acid composition, most prominently a relative deficit of linoleic acid.
View Article and Find Full Text PDFTrends in functional limitations among middle-aged and older adults in the Asia-Pacific: survey evidence from 778,507 observations across six countries.
Lancet Reg Health West Pac
January 2025
Nossal Institute for Global Health, School of Population and Global Health, The University of Melbourne, 32 Lincoln Square, Carlton, 3053, Australia.
Background: There are few studies comparing health status trends among middle-aged and older adults in countries currently experiencing a rapid demographic and economic transition in the Asia-Pacific, relative to their high-income regional counterparts. This study investigates trends in functional limitations among individuals aged 45 years and above in six major Asia-Pacific countries, ranging from middle- to high-income, from 2001 to 2019 and examines disparities across socioeconomic and demographic sub-groups.
Methods: Data on 778,507 individuals from seven surveys in three high-income countries (Australia, Japan, South Korea) and three middle-income countries (China, Indonesia, and India) were used.
Associations between potential risk factors and blood-brain barrier water permeability in middle-aged and older adults.
J Alzheimers Dis
January 2025
Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
Blood-brain barrier (BBB) dysfunction is suggested to be a potential mediator between vascular risk factors and cognitive impairment, leading to vascular cognitive impairment. To investigate the relationships between age, sex, and vascular risk factors and BBB water permeability as well as their relationship with cognition. To measure BBB permeability, a novel arterial spin labelling MRI technique (ME-ASL) was applied to derive the time of exchange (Tex), arterial time transit (ATT), and cerebral blood flow (CBF).
View Article and Find Full Text PDFAssociation between dairy products intake and frailty transitions in older adults: The InCHIANTI cohort study.
J Nutr Health Aging
January 2025
Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain; CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, 28029 Madrid, Spain.
Objective: To evaluate the association between dairy products consumption and the probability of frailty transitions in community-dwelling older adults.
Design: Longitudinal study.
Setting And Participants: We included 863 community-dwelling participants ≥65 years from the Chianti region in Italy.
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