Low-dose oral minoxidil for frontal fibrosing alopecia: a 122-patient case series.

Actas Dermosifiliogr

Departamento de Dermatología, Hospital Universitario Ramón y Cajal, IRYCIS, Universidad de Alcalá, Madrid, España; Unidad de Tricología, Grupo de Dermatología Pedro Jaén, Madrid, España.

Published: November 2024

AI Article Synopsis

  • * Out of 122 patients, 45.1% reported subjective improvements in hair density at the frontotemporal hairline, with varying degrees of improvement noted.
  • * While 57.4% of patients saw overall hair density improvements, 33.6% experienced adverse effects, primarily hypertrichosis; however, the findings suggest that oral minoxidil can enhance hair and eyebrow growth in FFA patients.

Article Abstract

The objective of our study was to analyze the effectiveness of oral minoxidil on the frontotemporal hairline in patients with FFA. We conducted a retrospective, descriptive, multicenter study in 2 Brazilian and 1 Spanish centers. Responses were graded on a scale of 3 positive points. A total of 122 patients were included. Subjective improvement in the density of the frontotemporal hairline was observed in 45.1% patients, which was categorized as mild (34.4%), moderate (9.0%), and excellent (1.6%). Hair density improved in 57.4% of the patients' interparietal. Additionally, 25.4% and 3.3% of the patients experienced eyebrow and eyelash growth, respectively. Adverse effects were detected in 33.6% patients, with hypertrichosis being the most common (23.8%). In this study, oral minoxidil proved to be an additional therapy for FFA that not only improved the patients' overall hair and eyebrow growth, but also the density of the frontotemporal hairline.

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http://dx.doi.org/10.1016/j.ad.2024.05.029DOI Listing

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