Fatty acid-binding protein 7 (FABP7) aids in the intracellular transport of endogenous cannabinoids and is involved in regulating the stress response system. This study examined the role of FABP7 in chronic stress exposure through the binding of CB1 receptors. Adult male FABP7 and FABP7 mice were treated with the unpredictable chronic mild stress (UCMS) procedure. After 28 days of treatment, mice were euthanized, and CB1 was measured with in vitro autoradiography using [3H] SR141716A. FABP7 mice, irrespective of stress treatment, showed reduced [3H] SR141716A binding in the amygdala, secondary somatosensory cortex, and ventral caudate putamen compared with the FABP7 mice. Additionally, FABP7 mice treated with UCMS exhibited a reduction in CB1 binding in the globus pallidus and ventral caudate putamen compared with UCMS-treated FABP7 mice. Genetic deletion of FABP7 can decrease CB1 expression in various brain regions; however, the underlying mechanism remains unclear.
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| http://dx.doi.org/10.1016/j.neulet.2024.138040 | DOI Listing |
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Article Synopsis
- FABP7 is a protein found in the brain that may help transport cannabinoids like THC, but its role in the endocannabinoid system is not fully understood.
- In a study using mice lacking FABP7, researchers measured THC and its metabolite 11-OH-THC levels after THC inhalation, finding that females with FABP7 deletion had lower levels of 11-OH-THC compared to those with the protein.
- The study also revealed that FABP7 influences endocannabinoid levels, showing females with FABP7 deletion had decreased levels of anandamide and increased levels of 2-AG, indicating a sex-specific role in THC metabolism and endocannabinoid regulation.
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