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Rethinking routine: selective postoperative laboratory testing is safe in emergency surgery patients.
Trauma Surg Acute Care Open
January 2025
Surgery, Cooper University Health Care, Camden, New Jersey, USA.
Novel clinical trial designs emerging from the molecular reclassification of cancer.
CA Cancer J Clin
January 2025
Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, USA.
Next-generation sequencing has revealed the disruptive reality that advanced/metastatic cancers have complex and individually distinct genomic landscapes, necessitating a rethinking of treatment strategies and clinical trial designs. Indeed, the molecular reclassification of cancer suggests that it is the molecular underpinnings of the disease, rather than the tissue of origin, that mostly drives outcomes. Consequently, oncology clinical trials have evolved from standard phase 1, 2, and 3 tissue-specific studies; to tissue-specific, biomarker-driven trials; to tissue-agnostic trials untethered from histology (all drug-centered designs); and, ultimately, to patient-centered, N-of-1 precision medicine studies in which each patient receives a personalized, biomarker-matched therapy/combination of drugs.
View Article and Find Full Text PDFSocial associations across species during nocturnal bird migration.
Curr Biol
January 2025
Cornell Lab of Ornithology, Cornell University, Ithaca, NY 14850, USA; Actions@EBMF, New York, NY 10006, USA.
An emerging frontier in ecology explores how organisms integrate social information into movement behavior and the extent to which information exchange occurs across species boundaries. Most migratory landbirds are thought to undertake nocturnal migratory flights independently, guided by endogenous programs and individual experience. Little research has addressed the potential for social information exchange aloft during nocturnal migration, but social influences that aid navigation, orientation, or survival could be valuable during high-risk migration periods.
View Article and Find Full Text PDFRethinking Cardiopulmonary Resuscitation: Bias, Compression Location, and Optimized Techniques.
Crit Care Med
January 2025
Department of Emergency Medicine, Central Hospital Affiliated to Shandong First Medical University, Jinan, China.
Rethinking the pan scan in stable trauma: A comparison of whole-body computed tomography and selective imaging in clinically stable blunt force trauma.
Emerg Med Australas
February 2025
Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
Objective: To compare the frequency of clinically significant missed injuries in clinically stable trauma patients undergoing initial whole-body computed tomography (WBCT) versus selective imaging. Secondary objectives include comparisons of radiation exposure, incidental findings, ED length of stay (LOS), hospital LOS and mortality.
Methods: We performed a retrospective cohort study of trauma activations at a tertiary trauma centre in patients with normal vital signs from 1st January 2022 to 31st December 2022.
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