Brodifacoum, a long-acting anticoagulant rodenticide, exerts inhibitory effects on blood coagulation factor synthesis, leading to abnormal clotting function and potential fatality. Poisoning of accidental exposure to brodifacoum is not rare, but death from brodifacoum poisoning can be largely avoided with timely and long-term effective treatments, consequently, forensic data on fatalities due to brodifacoum poisoning may be limited. This paper presents a case of brodifacoum-induced homicide, detailing the medial records and pathological changes observed in multiple organs. Furthermore, t liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to measure the concentrations of brodifacoum in blood, hydropericardium, and urine 40 days post-poisoning (1 day post-mortem), yielding values of 0.097 μg/mL, 0.089 μg/mL, and 0.007 μg/mL respectively. The aim of this article is to contribute towards forensic identification of fatalities resulting from brodifacoum poisoning while also serving as a reference for clinical diagnosis in similar cases.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jflm.2024.102784 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report.
Front Pharmacol
November 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Brodifacoum is a highly effective rodent poison that can cause serious bleeding issues (coagulopathy), but its effects during pregnancy are not well documented.
- A case study reported a pregnant woman experiencing severe bleeding due to brodifacoum poisoning, leading to serious complications and the loss of the fetus.
- Effective management of brodifacoum poisoning is essential, with timely recognition and treatment (like vitamin K1) needed to improve outcomes for pregnant patients.
Systematic forensic identification of a homicide by brodifacoum poisoning: A case report.
J Forensic Leg Med
November 2024
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:
Brodifacoum, a long-acting anticoagulant rodenticide, exerts inhibitory effects on blood coagulation factor synthesis, leading to abnormal clotting function and potential fatality. Poisoning of accidental exposure to brodifacoum is not rare, but death from brodifacoum poisoning can be largely avoided with timely and long-term effective treatments, consequently, forensic data on fatalities due to brodifacoum poisoning may be limited. This paper presents a case of brodifacoum-induced homicide, detailing the medial records and pathological changes observed in multiple organs.
View Article and Find Full Text PDFSecond-Generation Anticoagulant Rodenticide Toxicosis in a Wild Carnaby's Cockatoo ().
J Avian Med Surg
October 2024
School of Veterinary Medicine, Murdoch University, Murdoch, Western Australia 6151, Australia.
Article Synopsis
- * On Day 4, the bird experienced severe bleeding, nosebleeds, and anemia, leading to its euthanasia due to ongoing health decline.
- * Testing revealed high levels of anticoagulant rodenticides in its liver, marking the first recorded case of rodenticide poisoning in this wild Australian bird species.
Non-adherence with long-term oral vitamin K therapy in acute long-acting anticoagulant rodenticides poisoning: A call for action.
Toxicol Commun
April 2024
Department of Anesthesiology, University of Illinois College of Medicine in Chicago.
Widespread use of anticoagulant rodenticides in agricultural and urban environments. A menace to the viability of the endangered Bonelli's eagle (Aquila fasciata) populations.
Environ Pollut
October 2024
Service of Toxicology and Forensic Veterinary Medicine, Department of Health Sciences, Faculty of Veterinary Medicine, Campus de Espinardo, Universidad de Murcia, 30100, Murcia, Spain; Toxicology and Risk Assessment Research Group, IMIB-Pascual Parrilla, University of Murcia, 30120 El Palmar, Spain.
Article Synopsis
- * A study analyzed 17 Bonelli's eagle carcasses in Eastern Spain, finding that all had been exposed to at least 5 of the 10 ARs tested, with second generation ARs being the most common.
- * The significant presence of ARs in these eagles, along with liver concentrations suggesting potential poisoning, raises concerns about their impact on the eagle population and associated risks to public health due to the diet of these birds.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!