Prolactinomas account for more than half of pituitary adenomas, and besides their clinical impact on fertility and gonadal function, they lead to detrimental effects on bone. Patients with prolactinoma are prone to deterioration of bone structure caused not only by prolactin (PRL) induced hypogonadism but also by its direct actions on bone cells and calcium metabolism. However, clinical studies have shown inconsistent evidence regarding whether PRL could have a deleterious effect independently from gonadal insufficiency on skeletal integrity. Seminal studies from our group reported an increased prevalence of vertebral fractures (VFs) in both female and male patients with prolactinoma. Treatment of prolactinoma with dopamine agonists can restore gonadal function and improve bone mineral density. Since the presence of VFs may be related to more aggressive disease, bone comorbidities in prolactinoma should be managed by a multidisciplinary team in line with the recent concept of 'pituitary tumors centers of excellence'. The review aims to evaluate the mechanism of PRL actions on bone, as well as to provide practical indications for a modern approach to the management of skeletal complications of patients with prolactin-secreting adenoma considering different clinical characteristics and outcomes.
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http://dx.doi.org/10.1007/s11102-024-01469-x | DOI Listing |
J Health Organ Manag
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Health Sciences, Faculty of Social Sciences, Tampere University, Tampere, Finland.
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View Article and Find Full Text PDFArch Public Health
December 2024
Public Health and Tropical Medicine, James Cook University, Townsville, Queensland , 4811, Australia.
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View Article and Find Full Text PDFCurr Opin Chem Biol
December 2024
BioEmPiRe Centre for Structural Biological EPR Spectroscopy, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK; Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK. Electronic address:
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View Article and Find Full Text PDFMikrochim Acta
December 2024
Department of Analytical Chemistry and Food Technology, Environmental Sciences Institute (ICAM), University of Castilla-La Mancha, Avda. Carlos III S/N, 45071, Toledo, Spain.
Single particle inductively coupled plasma mass spectrometry (SP-ICP-MS) is a powerful tool for metallic nanoparticle (NP) characterisation in terms of concentration and, taking into account several assumptions, also size. However, this technique faces challenges, such as the intrinsic matrix effect, which significantly impact the results when analysing real complex samples. This issue is critical for the calculations of key SP-ICP-MS parameters ultimately altering the final outcomes.
View Article and Find Full Text PDFJ Eat Disord
December 2024
School of Social Sciences, Arts Design and Architecture, University of New South Wales, Sydney, Australia.
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