Nicotinamide-based VEGFR-2 inhibitors have good contribution in drug discovery. Development of novel nicotinamides as VEGFR-2 inhibitors. different and assays were conducted to evaluate the VEGFR-2 inhibition and cytotoxicity. Compound displayed strongest anti-VEGFR-2 potentiality and good anti-proliferative effects. Compound enhanced apoptosis and caused cell cycle arrest in the Pre-G1 and S phases. Compound boosted the level of the apoptotic caspase-3 and inhibited the level of TNF-α and IL-6 in tumor cells. Molecular docking and molecular dynamics (MD) simulations indicated the outstanding binding potential of compound against VEGFR-2. Compound is a good candidate for the creation of a novel antiangiogenic lead anticancer medication.
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