AI Article Synopsis
- * The Hippo signaling pathway, crucial for regulating organ size and tissue health, is linked to Yes-associated protein 1 (YAP1), which is found to be overexpressed in bladder cancer and associated with worse outcomes, including tumor recurrence and resistance to treatments.
- * The review focuses on how YAP1 contributes to the onset and progression of bladder cancer, while also exploring its potential role in improving diagnosis and treatment strategies for the disease.
Article Abstract
Bladder cancer is the most common malignant tumor of the urinary system with high morbidity and no clear pathogenesis. The Hippo signaling pathway is an evolutionarily conserved pathway that regulates organ size and maintains tissue homeostasis. Yes‑associated protein 1 (YAP1) is a key effector of this pathway and regulates downstream target genes by binding to transcriptional co‑activators with PDZ binding sequences (TAZ). Several studies have demonstrated that YAP1 is overexpressed in bladder cancer and is involved in adverse outcomes such as bladder cancer occurrence, progression, resistance to cisplatin and the recurrence of tumours. The present review summarized the involvement of YAP1 in bladder cancer disease onset and progression, and the mechanism of YAP1 involvement in bladder cancer treatment. In addition, this study further explored the potential of YAP1 in the diagnosis and treatment of bladder cancer. This study aimed to explore the potential mechanism of YAP1 in the treatment of bladder cancer.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599795 | PMC |
| http://dx.doi.org/10.3892/or.2024.8843 | DOI Listing |
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