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A Short Course of Standard Velcade/Dexamethasone Followed by Unlimited Weekly Maintenance Therapy Is an Effective Treatment in Relapsed/Refractory Multiple Myeloma.
Cancers (Basel)
November 2024
Herbert-Herman Cancer Center, University of Michigan Health-Sparrow, Lansing, MI 48912, USA.
Background: Bortezomib (B), known as Velcade, is a reversible proteasome inhibitor approved for relapsed/refractory multiple myeloma (RRMM) patients (pts). The standard of care protocol includes eight cycles of intravenous push (IVP) injections of B and oral dexamethasone (D), which increases the toxicity. Here, we describe the results of an open-label, phase II clinical trial employing only four cycles of B/D.
View Article and Find Full Text PDFShort-course subcutaneous alemtuzumab induces clinical responses in relapsed T-cell large granular leukemia.
Haematologica
November 2024
Division of Hematology, Department of Internal Medicine, James Comprehensive Cancer Center, The Ohio State University, Columbus, OH.
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View Article and Find Full Text PDFShort-course subcutaneous treatment with birch pollen allergoids greatly improves symptom and medication scores in birch allergy.
Allergy
November 2024
Department of Otorhinolaryngology, Technische Universität Dresden, Dresden, Germany.
Background: Subcutaneous immunotherapy has emerged as an effective option for treating allergic diseases. Here, we assessed the clinical impact of the mannan-conjugated birch pollen polymerized allergoid T502 in birch pollen-induced allergic rhinoconjunctivitis.
Methods: In this prospective, randomized, double-blind placebo-controlled phase III trial, 298 birch pollen-allergic adult patients were treated across 28 trial sites in Germany.
A Rare Presentation of Cysticercosis in the Sternocleidomastoid Muscle.
Cureus
May 2024
Department of Otolaryngology, Head and Neck Surgery, Dr. D. Y. Patil Medical College and Hospital, Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, IND.
Article Synopsis
- * The larval cysts typically form in the central nervous system, eyes, muscles, and occasionally other tissues, leading to nonspecific symptoms that complicate diagnosis.
- * In a unique case, cysticercus was found in the sternocleidomastoid muscle, diagnosed via ultrasonography and contrast scans, and treated with surgery and anthelmintics.
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Lancet
June 2024
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. Electronic address:
Article Synopsis
- A clinical trial called RADICALS-HD studied the effects of adding short-course androgen deprivation therapy (ADT) to postoperative radiotherapy in patients with localized prostate cancer after surgery.
- It involved 1480 patients, examining how ADT impacts metastasis-free survival compared to radiotherapy alone, and measured outcomes like distant metastasis and overall survival.
- The trial aimed to see if combining ADT with radiotherapy could improve the 10-year metastasis-free survival rate, potentially increasing it from 80% to 86%.
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