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| http://dx.doi.org/10.1177/15593258241301951 | DOI Listing |
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Negative spillover due to constraints on care delivery: a potential source of bias in pragmatic clinical trials.
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Background: Pragmatic clinical trials evaluate the effectiveness of health interventions in real-world settings. Negative spillover can arise in a pragmatic trial if the study intervention affects how scarce resources are allocated across patients in the intervention and comparison groups.
Main Body: Negative spillover can lead to overestimation of treatment effect and harm to patients assigned to usual care in trials of diverse health interventions.
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