Background: Migraine is one of the most debilitating neurological disorders that causes frequent attacks of headaches and affects approximately 11% of the global population. Deficient or even insufficient levels of vital nutrients would increase the severity and frequency of migraine attacks. Therefore, we aimed to examine the practical supplements for the prevention and management of migraine attacks.
Method: This narrative review study was conducted by searching PubMed, ISI web of science, EMBASE, Google Scholar, and Scopus using the keywords of "dietary supplement" and "migraine" plus their MeSH terms. Original articles published in English language from their inception to July 27th, 2024, studies that investigated adult population (aged >18 years), and those assessing the impact of intended nutrient supplementation on clinical symptoms of migraine were included in the study.
Result: Oxidative stress and low intake of antioxidants would be risk factors for migraine attacks by inducing inflammation. The secretion of inflammatory cytokines, such as tumor necrosis factor (TNF)-a, would lead to neuroinflammation and migraine episodes by increasing the cellular permeability and interactions. Evidence also indicated a direct association between phases of migraine attacks and calcitonin gene-related peptide (CGRP), mitochondrial disorders, monoaminergic pathway, disruption in brain energy metabolism, and higher serum levels of glutamate and homocysteine. Therefore, supplementation with nutrients involved in mitochondrial function, brain energy metabolism, and even methyl donors would relieve migraine attacks.
Conclusion: Evidence indicated that supplementation with riboflavin, omega-3 fatty acids, alpha lipoic acid, magnesium, probiotics, coenzyme Q10, ginger, and caffeine would have favorable effects on migraine patients. However, more prospective studies are required to evaluate the effect of other nutrients on migraine patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557489 | PMC |
| http://dx.doi.org/10.3389/fnut.2024.1433390 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A case report of neuronal intranuclear inclusion disease and literature review.
BMC Neurol
December 2024
Department of Neurology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China.
Neuronal intranuclear inclusion disease (NIID) is a rare progressive neurodegenerative disease with a characteristic pathological feature of eosinophilic hyaluronan inclusions in the nervous system and internal organs. The identification of GGC-repeat expansions in the Notch 2 N-terminal like C (NOTCH2NLC) gene facilitates the accurate diagnosis of NIID. Due to its rareness and high clinical heterogeneity, the diagnosis of NIID is often delayed or missed.
View Article and Find Full Text PDFCerebral blood flow and arterial responses in migraine: history and future perspectives.
J Headache Pain
December 2024
Translational Research Center and Danish Headache Center, Rigshospitalet, University of Copenhagen, Nordstjernevej 42, Glostrup, Copenhagen, 2600, Denmark.
Introduction: It is largely accepted that migraine with aura (MA) is caused by cortical spreading depression (CSD) and that migraine without aura (MO) is not. This is mostly based on old studies of regional cerebral blood flow (rCBF) and studies of vascular responses. These studies are partly forgotten today and may, therefore, be worthwhile reviewing.
View Article and Find Full Text PDFInvestigating the relationship between diet quality, lifestyle and healthy eating index with severity and migraine attacks: a cross-sectional study.
Front Nutr
December 2024
Department of Nutrition, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Background: Migraine is a disabling neurovascular disorder often associated with comorbidities such as mental health disorders, cardiovascular diseases, and metabolic syndromes. While certain dietary triggers have been identified, the impact of overall diet quality on migraine severity and frequency is not well understood. This study aimed to evaluate the association between diet quality, lifestyle factors, and the Healthy Eating Index (HEI) with migraine severity and frequency.
View Article and Find Full Text PDFCa3.2 T-type calcium channels contribute to CGRP- induced allodynia in a rodent model of experimental migraine.
J Headache Pain
December 2024
Department of Pharmacology, Biological Sciences Sector, Federal University of Parana, Curitiba, PR, Brazil.
Background: Migraine is a painful neurological syndrome characterized by attacks of throbbing headache, of moderate to severe intensity, which is associated with photo- and phono- sensitivity as well as nausea and vomiting. It affects about 15% of the world's population being 2-3 times more prevalent in females. The calcitonin gene-related peptide (CGRP) is a key mediator in the pathophysiology of migraine, and a significant advance in the field has been the development of anti-CGRP therapies.
View Article and Find Full Text PDFInterictal burden in migraine patients at the outset of CGRP monoclonal antibody prevention.
J Headache Pain
December 2024
Eli Lilly and Company, Indianapolis, IN, USA.
Background: The total burden of migraine includes not only the episodes with headache pain but extends throughout the interictal periods. Interictal symptoms and associated psychological responses may profoundly impact well-being and drive treatment-seeking behavior.
Methods: A cross-sectional online survey was conducted with participants aged ≥ 18 years, 250 with episodic migraine (EM) and 250 with chronic migraine (CM), having ≥ 4 monthly migraine headache days.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!