AI Article Synopsis

  • An emerging zoonotic pathogen linked to human granulocytic anaplasmosis was studied in small mammals to assess its prevalence, genetic diversity, and risk factors in western Yunnan province, China.
  • Through seasonal capture and nested-PCR testing on spleen samples, researchers found a 0.93% infection rate among 1,605 small mammals across various species and habitats, revealing significant variations in infection rates.
  • The study highlighted the pathogen's genetic diversity with distinct clades identified and underscored the importance of ongoing monitoring and the One Health approach for effective public health and disease surveillance.

Article Abstract

() is an emerging zoonotic pathogen causing human granulocytic anaplasmosis, linked to small mammal reservoirs that harbor various zoonotic pathogens, underscoring their importance in public health and ecology. This study seeks to determine the prevalence of in small mammals using PCR, then sequence and genotype positive samples, and assess infection risk factors. Small mammals were seasonally captured and a nested polymerase chain reaction (nested-PCR) was conducted targeting the 16S rRNA gene on spleen samples to detect infection from three counties in western Yunnan province, China. Positive samples were sequenced and genotyped, revealing genetic diversity and regional clustering of the pathogen. A total of 1,605 small mammals belonging to 30 species, 18 genera, 6 families, 3 orders were captured seasonally and screened in this region, yielding a 0.93% infection rate with (15/1605). Significant variations in infection rates were observed across different species, counties, and habitats. The 16Sr RNA genes of were categorized into two distinct clades, indicating notable genetic diversity. The identification of genetic variants in spleen samples underscores the potential public health risk and the critical importance of the One Health approach in disease surveillance. Our findings emphasize the necessity for continuous monitoring and highlight the value of nested-PCR testing on spleen samples for accurate prevalence assessment.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557534PMC
http://dx.doi.org/10.3389/fvets.2024.1472595DOI Listing

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