AI Article Synopsis
- - A new method is introduced for creating benzo-fused-γ-sultams through alkyl radical cyclization of vinyl sulfonamides.
- - The process involves Ag(I)-catalyzed decarboxylative alkylation using various carboxylic acids, including bulky ones like adamantanes, as alkyl sources.
- - This reaction is advantageous because it uses easily obtainable starting materials and can work with a wide range of substrates.
Article Abstract
A convenient method to access benzo-fused-γ-sultams alkyl radical induced cyclization of vinyl sulfonamides is presented. A wide range of carboxylic acids including sterically hindered adamantanes participated as alkyl donors in this Ag(I)-catalyzed decarboxylative alkylation. The reaction utilizes readily available starting materials and demonstrates a broad substrate scope.
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| http://dx.doi.org/10.1039/d4ob01583e | DOI Listing |
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