AI Article Synopsis
- - Identifying early biomarkers for neurodegeneration is essential, especially in patients with idiopathic REM sleep behavior disorder (iRBD), where changes in CD4 T cells may indicate risk.
- - A study followed iRBD patients to measure levels of specific transcription factors in CD4 T cells, using statistical methods to differentiate between those who converted to neurodegeneration and those who did not.
- - The findings reveal that certain mRNA levels in CD4 T cells can serve as promising predictive biomarkers, with significant hazard ratios indicating higher and lower levels are linked to increased risk of phenoconversion in iRBD patients.
Article Abstract
Early biomarkers of phenoconversion to neurodegeneration are crucial to identify individuals at high risk. In patients with idiopathic REM sleep behavior disorder (iRBD), the strongest risk factor for neurodegeneration, CD4 T cells exhibit a peculiar transcription factor pattern. To assess transcription factor mRNA levels in CD4 T cells as predictive biomarkers of phenoconversion in iRBD patients. iRBD patients were followed prospectively. ROC curve analysis and Kaplan-Meier curves were used to assess the discrimination between converters and non-converters. CD4 T cells from converters had higher , and lower and mRNA levels. Hazard ratio was 58.3 (95% CI: 6.2-547.1) for higher , 101.2 (95% CI: 16.8-609.4) for lower and 15.7 (2.7-91.4) for lower . , and mRNA levels in CD4 T cells are promising predictive biomarkers of phenoconversion in iRBD patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572078 | PMC |
| http://dx.doi.org/10.1080/20565623.2024.2418821 | DOI Listing |
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