This work demonstrates a spatial-division multiplexing self-healing ring protection scheme. A 3-node, 2-fiber ring with a recirculating length of 139.3 km is implemented using 4-core weakly-coupled multicore working and protection fibers and supported by core-pumped multicore amplifiers. Each node implements a spatial channel switching scheme with 8×8 traffic switches and arrays of 2×2 MEMS switches for ring protection switching with fiber bending taps to simultaneously monitor the power on all cores of the working and protection fibers. We achieve an average loss around 2 dB per network element along the protection path, which enables the use of ring protection with minimal performance impact. With this scheme, we demonstrate the protection of a line-side traffic throughput above 120 Tb/s using polarization-multiplexed 16-ary quadrature-amplitude modulation signals across the C-band.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1364/OE.524142 | DOI Listing |
PLoS One
January 2025
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.
End-user feedback early in product development is important for optimizing multipurpose prevention technologies for HIV and pregnancy prevention. We evaluated the acceptability of the 90-day dapivirine levonorgestrel ring (DPV-LNG ring) used for 14 days compared to a dapivirine-only ring (DVR-200mg) in MTN-030/IPM 041 (n = 23), and when used for 90 days cyclically or continuously in MTN-044/IPM 053/CCN019 (n = 25). We enrolled healthy, non-pregnant, HIV-negative women aged 18-45 in Pittsburgh, PA and Birmingham, AL (MTN-030 only).
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
January 2025
Department of Biochemistry and Molecular Biology, Dalhousie University, Dalhousie Medicine New Brunswick, 355 Campus Ring Road, Saint John, New Brunswick, E2L 4L5, Canada.
Lipid phosphate phosphatase 3 (LPP3) is a membrane-bound enzyme that hydrolyzes lipid phosphates including the bioactive lipid, lysophosphatidic acid (LPA). Elevated circulating LPA production and cellular LPA signaling are implicated in obesity-induced metabolic and cardiac dysfunction. Deletion of LPP3 in the cardiomyocyte increases circulating LPA levels and causes heart failure and mitochondrial dysfunction in mice.
View Article and Find Full Text PDFInt J Biol Macromol
January 2025
Biomaterials Department, Institute of Industrial Nanomaterials, Kumamoto University, Kumamoto 860-8555, Japan. Electronic address:
The global rise of bacterial resistance demands innovative strategies to enhance antibiotic efficacy. This study investigates keratin nanoparticles (KNPs) derived from waste chicken feathers as sustainable drug carriers. Antibacterial activity of KNPs was evaluated against Staphylococcus aureus and Escherichia coli using antibacterial sensitivity assays, including disc diffusion and minimum inhibitory concentration tests, while cytotoxicity was evaluated on human lymphoma cells.
View Article and Find Full Text PDFBiomater Adv
January 2025
College of Medical Technology and Engineering, Henan University of Science and Technology, Luoyang 471023, China.
Hydrogels possessing appropriate adhesion and antibacterial properties have emerged as promising dressings for expediting wound healing, while also providing the convenience of visualizing the wound site to accurately monitor the healing process. In this study, we incorporated oxidized and degraded polydopamine nanoparticles into quaternized chitosan/oxidized dextran hydrogel QOP series, resulting in enhanced transmittance exceeding 95 % and adhesion strengths reaching up to 19.4 kPa.
View Article and Find Full Text PDFMolecules
January 2025
Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, 142432 Chernogolovka, Russia.
Artemisinin is a sesquiterpene lactone derived from the plant L., renowned for its antimalarial activity. Based on this compound, various derivatives and analogues have been obtained that exhibit diverse biological activities, including clinically approved drugs.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!