AI Article Synopsis
- GHRH was discovered over 40 years ago and plays a key role in stimulating growth hormone production in the pituitary gland, but its functions have expanded to include various biological activities.
- Research indicates that GHRH and its analogues can influence multiple health issues, such as cell growth, immune functions, mood disorders, and several diseases, including diabetes and cancer.
- The promising results from laboratory studies suggest that GHRH agonists and antagonists could be developed into effective clinical treatments for various medical conditions.
Article Abstract
Growth hormone-releasing hormone (GHRH) and its ability to stimulate the production and release of growth hormone from the pituitary were discovered more than four decades ago. Since then, this hormone has been studied extensively and research into its functions is still ongoing. GHRH has multifaceted roles beyond the originally identified functions that encompass a variety of direct extrapituitary effects. In this Review, we illustrate the different biological activities of GHRH, covering the effects of GHRH agonists and antagonists in physiological and pathological contexts, along with the underlying mechanisms. GHRH and GHRH analogues have been implicated in cell growth, wound healing, cell death, inflammation, immune functions, mood disorders, feeding behaviour, neuroprotection, diabetes mellitus and obesity, as well as cardiovascular, lung and neurodegenerative diseases and some cancers. The positive effects observed in preclinical models in vitro and in vivo strongly support the potential use of GHRH agonists and antagonists as clinical therapeutics.
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| http://dx.doi.org/10.1038/s41574-024-01052-1 | DOI Listing |
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