Psoriasis and risk of new-onset degenerative valvular heart disease: a prospective cohort study.

Eur Heart J Qual Care Clin Outcomes

Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, No.167 Beilishi Road, Xicheng District, Beijing 100037, China.

Published: November 2024

AI Article Synopsis

  • The study investigates the relationship between psoriasis and degenerative valvular heart disease (VHD), finding that both share common risk factors and inflammatory conditions.
  • Utilizing data from the UK Biobank, researchers analyzed the incidence of various types of VHD among participants with and without psoriasis over a median follow-up period of around 13.7 years.
  • Results showed that participants with psoriasis had a higher risk of developing aortic stenosis (AS), particularly among women, whereas no significant links were found for other forms of degenerative VHD.

Article Abstract

Background: Recent evidence indicates that degenerative valvular heart disease (VHD) and psoriasis share overlapping risk factors and simultaneous presence of inflammation, yet this relationship has not been thoroughly explored.

Methods: Drawing on the prospective cohort data from the UK Biobank, baseline information on psoriasis and the incidence of eight specific types of degenerative VHD-aortic stenosis (AS), aortic regurgitation, mitral stenosis, mitral regurgitation, tricuspid stenosis, tricuspid regurgitation, pulmonary stenosis, and pulmonary regurgitation-during the follow-up period were recorded. Cox proportional hazards models were conducted to estimate the association between psoriasis and the risk of degenerative VHD, adjusted for demographic indicators, lifestyle factors, comorbidities, and medication.

Results: A total of 494 510 participants were included in the study. Among the participants without psoriasis, 13 672 events of degenerative VHD were observed during a median follow-up of 13.78 years, yielding an incidence rate of 2.14 per 1 000 person-years. In contrast, In the psoriasis group (n = 10 917), 422 events of degenerative VHD were reported during a median follow-up of 13.70 years, corresponding to an incidence rate of 2.93 per 1 000 person-years. After fully adjusting, participants with psoriasis had a significantly increased risk of AS (HR, 1.24; 95% CI, 1.07-1.43), yet no significant associations were observed between psoriasis and the risk of other degenerative valve diseases. In sex subgroup analyses, there was an interaction between sex and psoriasis in the occurrence of AS (p-interaction = 0.039), suggesting a high risk in women.

Conclusions: Psoriasis was significantly associated with the risk of new-onset AS and may be more distinct in females, while no significant associations were observed between psoriasis and the risk of developing other degenerative valve diseases.

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Source
http://dx.doi.org/10.1093/ehjqcco/qcae096DOI Listing

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