AI Article Synopsis

  • The study investigates how microcirculation alterations can indicate vascular pathologies, particularly through methods like contrast enhanced ultrasound (CEUS) and super-resolution ultrasound (SRU) imaging.
  • CEUS showed limitations in accurately measuring blood flow in microvascular areas due to interference from larger vessels and varying degrees of blood flow redistribution, which affected correlation with actual flow rates.
  • In contrast, SRU demonstrated high accuracy in depicting blood vessel structures and dynamics, achieving over 91% correspondence with ground truth measurements, suggesting it may be a more effective tool for studying subtle flow changes caused by ischaemia.

Article Abstract

The study of microcirculation can reveal important information related to pathology. Focusing on alterations that are represented by an obstruction of blood flow in microcirculatory regions may provide an insight into vascular biomarkers. The current in silico study assesses the capability of contrast enhanced ultrasound (CEUS) and super-resolution ultrasound imaging (SRU) flow-quantification to study occlusive actions in a microvascular bed, particularly the ability to characterise known and model induced flow behaviours. The aim is to investigate theoretical limits with the use of CEUS and SRU in order to propose realistic biomarker targets relevant for clinical diagnosis. Results from CEUS flow parameters display limitations congruent with prior investigations. Conventional resolution limits lead to signals dominated by large vessels, making discrimination of microvasculature specific signals difficult. Additionally, some occlusions lead to weakened parametric correlation against flow rate in the remainder of the network. Loss of correlation is dependent on the degree to which flow is redistributed, with comparatively minor redistribution correlating in accordance with ground truth measurements for change in mean transit time,dMTT(CEUS, = 0.85; GT, = 0.82) and change in peak intensity,dIp(CEUS, = 0.87; GT, = 0.96). Major redistributions, however, result in a loss of correlation, demonstrating that the effectiveness of time-intensity curve parameters is influenced by the site of occlusion. Conversely, results from SRU processing provides accurate depiction of the anatomy and dynamics present in the vascular bed, that extends to individual microvessels. Correspondence between model vessel structure displayed in SRU maps with the ground truth was>91%for cases of minor and major flow redistributions. In conclusion, SRU appears to be a highly promising technology in the quantification of subtle flow phenomena due ischaemia induced vascular flow redistribution.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11583374PMC
http://dx.doi.org/10.1088/1361-6560/ad9231DOI Listing

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