The cocktail enzyme-assisted natural deep eutectic solvent (CE-NADES) has been tailored for the efficient extraction of capsaicin, the characteristic bioactive compound of chili peppers (CPs), in this study. The extraction procedures were optimized as choline chloride:1,4-butanediol (molar ratio 1:3), extraction temperature 38 °C, liquid-solid ratio 27.5 mL/g, water content 17.8 % (v/v) and extraction time 28 min, which yield was 9.91 ± 0.13 mg/g. Moreover, CE pretreatment, by destroying plant structures, accelerated the release of capsaicin and consequently reduced the maximum decomposition temperature of CP residues to 260.5 °C after extraction. Meanwhile, more hydrogen bonds (134.72 at lifetime 3.98 ps) formed between capsaicin and NADES to facilitate the mass transfer. Larger solvent accessible surface area (210.09 nm) and lower average interaction energy (-455.12 kJ/mol) enhanced the stability and solubility of capsaicin. Overall, CE-NADES could serve as an industrialized and green alternative method for the efficient extraction of capsaicin.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.foodchem.2024.141959 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Behavioral assessment to evaluate the analgesic and anti-inflammatory effects of Fagonia bruguieri var. laxa boiss by targeting pro-inflammatory cytokines and prostaglandin pathways.
J Ethnopharmacol
January 2025
College of Pharmacy, Shenzhen Technology University, Shenzhen, 518118, Guangdong, China; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, 90112, Songkhla, Thailand; Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai, 90112, Songkhla, Thailand. Electronic address:
Ethnopharmacological Relevance: Fagonia bruguieri var. laxa Boiss., also known as Dhamansa or Dhamaran, is a well-known xerophyte traditionally used for managing pain, inflammation, fever, and related disease conditions.
View Article and Find Full Text PDFQuality by Design-Steered Chromatographic Separation and Identification of the Geometric Isomers of Capsiate by Reversed-Phase HPLC and LC-MS.
J Chromatogr Sci
January 2025
Nutrition and Bromatology Group, Department of Analytical Chemistry and Food Science, Faculty of Science, Universidade de Vigo, E-32004 Ourense, Spain.
An efficient reverse-phase high-performance liquid chromatographic method, based on the design of the experiment approach, was developed for the simultaneous determination of capsiate isomers. Critical method parameters, i.e.
View Article and Find Full Text PDFEffects of Capsicum Oleoresin on the Energy Expenditure and Mitochondrial Content of Brown Adipose Tissue in Mice Fed a High-Fat Diet.
Prev Nutr Food Sci
December 2024
Department of Nutritional Science and Food Management, Ewha Womans University, Seoul 03760, Korea.
Capsicum oleoresin (CO) is a concentrated extract derived from peppers ( L.) containing capsaicin (the active compound responsible for its pungency) and other bioactive components. The present study aimed to determine whether CO affects the energy expenditure and mitochondrial content of brown adipose tissue (BAT) in diet-induced obese mice.
View Article and Find Full Text PDFEmerging Therapeutic Modalities and Pharmacotherapies in Neuropathic Pain Management: A Systematic Review and Meta-Analysis of Parallel Randomized Controlled Trials.
Pain Res Manag
January 2025
Statistics Unit, Riga Stradinš University, 16 Dzirciema Street, Riga LV-1007, Latvia.
Neuropathic pain (NP) is a chronic condition caused by abnormal neuronal excitability in the nervous system. Current treatments for NP are often ineffective or poorly tolerated. Hence, we reviewed the efficacy and safety of novel drugs or devices that target neuronal excitability in NP patients compared with placebo, sham, or usual care interventions.
View Article and Find Full Text PDFUPLC-PDA-ESI-MS based chemometric analysis for solvent polarity effect evaluation on phytochemical compounds and antioxidant activity in habanero pepper (Capsicum chinense Jacq) fruit extract.
J Food Sci
January 2025
Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco (CIATEJ) Unidad Sureste, Tablaje Catastral Km 5.5 Carretera Sierra Papacal-Chuburná Puerto, Parque Científico Tecnológico de, Yucatán, Mexico.
The effect of solvents with different polarities on the recovery of phytochemicals (carotenoids, capsaicinoids, and phenolic compounds) from habanero pepper (Capsicum chinense) and their association with antioxidant activity (ABTS and DPPH) was evaluated through Ultra-Performance-Liquid Chromatography coupled with a Photodiode Array Detector and a Electrospray Ionization Mass Spectrometry (UPLC-PDA-ESI-MS)-based chemometric analysis, including linear correlation, multiple linear regression, and principal component analysis (PCA). The solvent polarity scale was established according to solvent dielectric constants (ɛ). Color variation (ΔE) was used to determine the presence of carotenoids, with the highest ΔE obtained using low-polarity solvents (hexane and ethyl acetate).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!