AI Article Synopsis
- Fluoroquinolones play a crucial role in treating tuberculosis, so it's important to detect any resistance to these drugs.
- A comprehensive survey in England examined over 16,000 tuberculosis isolates and found an overall fluoroquinolone resistance rate of 1.4%, with 23.9% in multidrug-resistant TB cases.
- Implementing routine sequencing for resistance detection is recommended as a necessary strategy for monitoring and managing tuberculosis treatment.
Article Abstract
Fluoroquinolones are an important component of anti-tuberculosis treatment and identifying fluoroquinolone resistance is essential. We present the first survey of fluoroquinolone resistance in England from sequencing of over 16,000 unselected isolates. Fluoroquinolone resistance was 1.4% overall and 23.9% in multidrug-resistant TB. Routine sequencing allows resistance surveillance and should be widely adopted.
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| http://dx.doi.org/10.1093/cid/ciae560 | DOI Listing |
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