AI Article Synopsis
- Photodynamic therapy (PDT) is gaining attention for potentially reducing chemotherapy side effects and enhancing patients’ quality of life, but many PDT drugs struggle with poor absorption and effectiveness.
- This article examines a specific PDT drug, temoporfin (Foscan), combined with β-cyclodextrin units as carriers to improve its delivery to cells.
- All-atom simulations demonstrate that the drug complex can penetrate lipid membranes and may dissociate within, supporting the idea that this method could enhance drug efficacy in PDT applications.
Article Abstract
Photodynamic therapy (PDT) represents a most attractive therapeutic strategy to reduce side-effects of chemotherapy and improve the global quality of life of patients. Yet, many PDT drugs suffer from poor bioavailability and cellular intake, and thus, drug-delivering strategies are mandatory. In this article, we rationalize the behavior of a temoporfin-based PDT drug, commercialized under the name of Foscan, complexed by two β-cyclodextrin units, acting as drug carriers, in the presence of a lipid bilayer. Our all-atom simulations have unequivocally shown the internalization of the drug-delivering complex and suggest its possible spontaneous dissociation in the lipid bilayer core. The factors favoring penetration and dissociation have also been analyzed, together with membrane perturbation due to the interaction with the drug carrier complex. Our results confirm the suitability of this encapsulation strategy for PDT and rationalize the experimental results concerning its efficacy.
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| http://dx.doi.org/10.1021/acs.jpcb.4c06087 | DOI Listing |
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