AI Article Synopsis

  • * DEX can be administered in various ways during and after surgery, but studies show inconsistent results regarding its effectiveness on sleep.
  • * Future research directions are needed to better understand how DEX affects postoperative sleep and to clarify the mechanisms at play, which could inform the design of upcoming studies.

Article Abstract

There is a high incidence of postoperative sleep and sleep architecture disorders in patients undergoing surgery, and dexmedetomidine (DEX) is commonly used to improve postoperative sleep quality and ameliorate the adverse effects of poor sleep on various organ systems. The continuous intraoperative intravenous infusion of DEX, the addition of DEX to postoperative intravenous analgesia pumps, and the continuous infusion of DEX after admission to the intensive care unit are often used clinically to improve postoperative sleep quality at doses of 0.1 to 0.7 μg/kg/hour, but the effects of DEX on sleep quality and structure identified in these studies have been inconsistent. Thus, it is unclear whether DEX improves postoperative sleep quality. The various methods of administering DEX to improve postoperative sleep quality have differing effects, the route used modifies the effect of DEX on sleep structure, and the intrinsic mechanism whereby DEX improves sleep quality remains to be fully investigated. In the present review, we describe new directions for future research into the effects of DEX on postoperative sleep quality and the mechanisms involved, which should help guide the design of further studies. This narrative review was completed according to the Scale for the Assessment of Narrative Review Articles (SANRA).

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11558704PMC
http://dx.doi.org/10.1177/03000605241290715DOI Listing

Publication Analysis

Top Keywords

sleep quality
32
postoperative sleep
28
improve postoperative
16
sleep
12
dex
10
postoperative
8
quality
8
patients undergoing
8
undergoing surgery
8
infusion dex
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!