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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551515PMC
http://dx.doi.org/10.1016/j.vgie.2024.07.001DOI Listing

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The Baveno VII consensus, released in 2023, recommends that the endoscopic treatment of choice for managing bleeding gastric varices (GV) is endoscopic ultrasound (EUS)-guided treatment, specifically EUS-guided cyanoacrylate (CYA) glue injection. This approach has been endorsed due to its efficacy in controlling bleeding while reducing rebleeding rates, compared to other endoscopic techniques. Despite its efficacy, CYA injection for GV has been linked to rare but serious adverse events, such as glue embolization leading to pulmonary embolism, infection/bacteremia, splenic infarction, intra-procedural and post-procedural complications.

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Endoscopic devices and techniques for the management of gastric varices (with videos).

Gastrointest Endosc

October 2024

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

Background And Aims: Gastric variceal bleeding occurs less commonly than bleeding from esophageal varices (EVs), although it is associated with higher morbidity and mortality. Bleeding from gastroesophageal varices type 1 (GOV1) is treated like EVs. In contrast, other forms of gastric variceal bleeding, including gastroesophageal varices type 2 (GOV2) and isolated gastric varices types 1 (IGV1) and 2 (IGV2), are treated with varying endoscopic approaches.

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Article Synopsis
  • Endoscopic ultrasound (EUS) guided coil plus glue injection is a newer, effective method for treating gastric varices, but limited comparisons exist with endoscopic glue injection (EGI).
  • A systematic review analyzed six studies involving 445 patients, showing EUS significantly lowers rebleeding and reintervention rates compared to EGI.
  • No major differences were found between the two methods regarding pulmonary embolism, mortality, technical success, fever, or abdominal pain.
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Article Synopsis
  • Endoscopic ultrasound (EUS) has transitioned from being solely a diagnostic tool to an interventional method that allows for precise treatment options, particularly in vascular access and therapy related to liver diseases.* -
  • EUS-guided procedures, like measuring portal pressure gradients and sampling portal venous blood, play a key role in diagnosing and managing various cancers and liver conditions, such as hepatocellular carcinoma and portal vein tumor thrombus.* -
  • The application of EUS is expanding to include treatments for complications like pseudoaneurysms and gastrointestinal bleeding, highlighting its growing importance in modern medical practice for both current and future therapeutic interventions.*
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