AI Article Synopsis
- A study identified seven unique compounds from a Chinese endemic plant, including six triterpenoids and one anthraquinone.
- The identified compounds displayed various health benefits, such as significant tyrosinase and antioxidant activity, as well as moderate α-glucosidase inhibitory effects.
- This research provides the first comprehensive insight into the chemical and biological properties of the plant's secondary metabolites, utilizing molecular docking to understand their interactions with specific proteins.
Article Abstract
There has been no phytochemical or and pharmacological report of the Chinese endemic plant till now. At present, seven structurally diverse compounds were obtained, including six triterpenoids (-) and one anthraquinone (). Interestingly, - furnished three distinct carbon skeletons. Additionally, these phytochemical constituents showed multiple health-promoting effects. Triterpene displayed considerable tyrosinase inhibitory activity (IC = 5.42 μM). Components and demonstrated significant antioxidant activity (IC = 4.23 and 2.03 mM, respectively). Meanwhile, compounds and exhibited moderate α-glucosidase inhibitory activity (IC = 0.89 and 0.72 mM, respectively). Moreover, the binding mechanisms for bioactive compounds , and and the corresponding α-glucosidase and tyrosinase proteins were preliminarily inspected by molecular docking experiments. This study filled up the knowledge gap of the unexplored chemical and biological profiles of secondary metabolites from the plant for the first time.
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| http://dx.doi.org/10.1080/14786419.2024.2425808 | DOI Listing |
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