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Deep Learning-Based Visual Complexity Analysis of Electroencephalography Time-Frequency Images: Can It Localize the Epileptogenic Zone in the Brain?
Algorithms
December 2023
Fetal-Neonatal Neuroimaging and Developmental Science Center, Division of Newborn Medicine, Department of Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Article Synopsis
- In drug-resistant epilepsy, the study focuses on using deep learning to analyze intracranial electroencephalography (iEEG) signals, specifically through time-frequency (TF) images, to locate the epileptogenic zone (EZ) for surgical guidance.
- The researchers processed iEEG data from 20 children and employed a pre-trained neural network (VGG16) to measure visual complexity, revealing that contacts within the seizure onset zone had significantly lower activation energy compared to those outside.
- The findings suggest a new computer-assisted method for accurately localizing the EZ with a 7 mm accuracy in MRI scans, potentially reducing the need for extensive manual iEEG examinations.
Effectiveness of sodium channel blockers in treating neonatal seizures due to arterial ischemic stroke.
Epilepsia
November 2024
Department of Pediatrics, Division of Pediatric Neurology, Saint-Luc University Hospital, Université Catholique de Louvain, Brussels, Belgium.
Objective: Few studies have evaluated the efficacy of antiseizure medications (ASMs) according to the etiology of neonatal acute provoked seizures. We aimed to investigate the response to ASMs in term/near term neonates with acute arterial ischemic stroke (AIS), as well as the type of seizure at presentation and the monitoring approach.
Methods: We retrospectively evaluated neonates from 15 European level IV neonatal intensive care units who presented with seizures due to AIS and were monitored by continuous electroencephalography (cEEG) and/or amplitude-integrated EEG (aEEG) in whom actual recordings, timing, doses, and response to ASMs were available for review.
Elucidating the genomic basis of rare pediatric neurological diseases in Central Asia and Transcaucasia.
Nat Genet
December 2024
Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, London, UK.
Chorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.
J Pediatr
December 2024
Division of Neonatology, Department of Pediatrics, Fetal Neonatal Institute, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA.
Objective: To determine if chorioamnionitis is associated with an increased risk of adverse 2-year outcomes among infants with hypoxic-ischemic encephalopathy (HIE).
Study Design: This cohort study included all infants with moderate to severe HIE treated with therapeutic hypothermia and enrolled on the High-dose Erythropoietin for Asphyxia and Encephalopathy Trial. Clinical chorioamnionitis (CC) was defined as a diagnosis made by a treating obstetrician and histologic chorioamnionitis (HC) was defined as placental inflammation observed on histology.
Providing pediatric neurocritical education across the ages: Bridging of neonatal neurocritical care into pediatric neurocritical care training.
Semin Fetal Neonatal Med
November 2024
Department of Pediatrics, Division of Neurology, Northwestern University Feinberg School of Medicine, 225 E Chicago Ave, Box 51, Chicago, IL, 60611, United States.
Pediatric neurocritical care is a field dedicated to providing specialized assessment and care of critically-ill children with neurologic disease or at risk of neurologic compromise. Fellowship programs for providers interested in specializing in pediatric neurocritical care are growing and developing to meet the needs of trainees and the patient populations that they serve. Fetal and neonatal neurocritical care fellowship remains a separate opportunity for training; however, inclusion of fetal and neonatal neurology education into pediatric neurocritical care broadens understanding of normal and pathologic anatomy and physiology, diagnostic interpretation of the developing brain, targeted management interventions, family counseling and prognostication, and long-term optimization of outcomes.
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