Noninvasive surface-enhanced Raman spectroscopy outperforms combined positive score in predicting sensitivity to neoadjuvant immunotherapy in head and neck squamous cell carcinoma.

Oral Oncol

State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Department of Head and Neck Oncology Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China. Electronic address:

Published: December 2024

Background: Head and neck squamous cell carcinoma poses a formidable treatment challenge owing to its complex anatomy and essential functions of the organs involved. Neoadjuvant immunotherapies, particularly PD-1 inhibitors, have shown promise in improving patient outcomes. Nevertheless, the ability to accurately predict which patients will benefit from neoadjuvant immunotherapy continues to be a significant hurdle.

Methods: We investigated 46 patients diagnosed with head and neck squamous cell carcinoma. Combined positive score was assessed before treatment. Serum samples were collected both before and after neoadjuvant immunotherapy, and subsequently analyzed utilizing surface-enhanced Raman spectroscopy.

Results: Significant differences in Raman spectral peaks were observed between the partial response and stable disease groups before treatment, particularly in the regions of 516-525 cm, 1240-1400 cm, 1600-1636 cm, and 1647-1680 cm. These peaks represent different cancer-related biochemical components, including protein and nucleic acid vibrations, disulfide bonds, amide III bands, CH2/CH3 deformations, and amide I bands. Principal Component Analysis-Linear Discriminant Analysis and Receiver Operating Characteristic analysis demonstrated that surface-enhanced Raman spectroscopy exhibited remarkable sensitivity and specificity, surpassing the combined positive score in assessing patient responses to neoadjuvant immunotherapy.

Conclusion: Surface-enhanced Raman spectroscopy offers significant potential to surpass the conventional combined positive score in predicting responses to neoadjuvant immunotherapy.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.oraloncology.2024.107105DOI Listing

Publication Analysis

Top Keywords

surface-enhanced raman
16
combined positive
16
positive score
16
neoadjuvant immunotherapy
16
raman spectroscopy
12
head neck
12
neck squamous
12
squamous cell
12
cell carcinoma
12
score predicting
8

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!