Introduction: We present a new technique, the bilobed lateral artery perforator-based flap, for breast-conserving surgery of large central tumors or nearby, combining Zymany's bilobed flap and a Lateral Intercostal Perforator (LICAP) flap, and its 10-year outcomes.
Materials And Methods: We studied 37 patients with malignant breast tumors near or involving the central skin, without ptosis or desire to correct it, who avoided mastectomy with this modified bilobed flap from 2013 to 2022. The same surgeon operated on them in different institutions. This research project was approved by our ethical committee (n. 2.322.212).
Results: The mean age was 57.17 (±12.60) years. The mean specimen weight was 74.32 (±25.84)g, and the mean tumor size was 40.35 (±15.81) mm. Fourteen (37.84 %) tumors were larger than 5 cm and one was multicentric. Thirty-two (86.49 %) patients had invasive ductal carcinomas. Nipple areola complex was removed in 19 (51.35 %) cases due to clinical involvement, and immediately reconstructed in two cases with contralateral free grafting. Twenty-one (56.76 %) patients received neoadjuvant chemotherapy. Three (8.11 %) patients had immediate contralateral mastopexy. Radiotherapy was indicated in all cases. There were 3 (8.11 %) minor complications, one positive margin, and no surgical revisions. In a mean follow-up of 39.97 (±29.43) months, there were no local recurrences, 2 metastasis, and one death. Satisfaction and aesthetic results were good or excellent in most cases.
Conclusions: The new technique enabled breast conservation, with high rates of free margins, high levels of satisfaction, few complications in women with large central tumors on small breasts with limited ptosis.
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http://dx.doi.org/10.1016/j.suronc.2024.102161 | DOI Listing |
PeerJ
December 2024
Department of Earth and Environmental Sciences, University of Manchester, Manchester, United Kingdom.
Zootaxa
May 2024
Laboratório de Entomologia; Departamento de Zoologia; Instituto de Biologia; Universidade Federal do Rio de Janeiro.
Six new species of Curtara are described, all with type-locality at Parque Nacional do Itatiaia, Itatiaia municipality, Rio de Janeiro State, Brazil: (1) Curtara (Curtara) andresi sp. nov. with the posterodorsal margin of the male pygofer forming a slightly sclerotized triangular projection and curved internally, style with apex rounded with dorsal spine, aedeagus with a pair of elongated falcate atrial processes, and shaft with a pair of short lateral subapical processes, directed ventrally; (2) Curtara (C.
View Article and Find Full Text PDFSurg Oncol
December 2024
Gynecology and Breast Unit, Araújo Jorge Cancer Hospital, Brazil; Mastology Program, Federal University of Goias, Brazil.
Sci Rep
June 2024
Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.
We report the first cryoEM structure of the Hendra henipavirus nucleoprotein in complex with RNA, at 3.5 Å resolution, derived from single particle analysis of a double homotetradecameric RNA-bound N protein ring assembly exhibiting D14 symmetry. The structure of the HeV N protein adopts the common bi-lobed paramyxoviral N protein fold; the N-terminal and C-terminal globular domains are bisected by an RNA binding cleft containing six RNA nucleotides and are flanked by the N-terminal and C-terminal arms, respectively.
View Article and Find Full Text PDFAdv Exp Med Biol
June 2024
Cardiovascular Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Situs abnormalities may occur in many and most often more complex congenital cardiac malformations. These conditions are collectively referred to as heterotaxy syndromes, derived from the Greek words "heteros" meaning different and "taxos" meaning orientation or arrangement. Clinically, heterotaxy spectrum encompasses defects in the left-right laterality and arrangement of visceral organs.
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