At the population level, accelerated aging can manifest itself as an early manifestation of age-associated pathology. Earlier, as an indicator of the order of manifestation of various diseases, we substantiated the age-specific incidence index (ASII), which is the ratio of the primary incidence rate among people over working age to the same indicator for the entire adult population. At the same time, it seems necessary to explain the mathematical relationship between median age and ASII. The purpose of the study: mathematically prove the applicability of the age-specific incidence index as an indirect indicator of the median age of patients. The materials were data from medical reporting forms on the appeal to the clinic with a newly diagnosed. The median age was estimated using the interval series calculation formula. The median age of patients calculated using the interval series calculation formula was 50.6 years. Having compiled and transformed the system of equations, the formula for calculating the median age using ASII was obtained. Calculation with the modified formula showed a similar median age. From a clinical perspective, the early development of age-related diseases is identical to premature aging. In the future, the mathematically proven ASII indicator will make it possible to develop a strategy for screening premature aging, and will also become one of the tools for the promising direction of gerontology - biohorology. Thus, the mathematical relationship between ASII and median age is demonstrated. The validity of the use of ASII as an indicator of the median age of the patient and, as a result, the age of manifestation of the disease at the population level was statistically proven.
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